KAP1 anticorps

N° du produit ABIN645876

Cet anticorps anti-KAP1 not_set Chèvre (ABIN645876) détecte spécifiquement KAP1. L’anticorps est réactif avec des échantillons de Humain et Souris.

Aperçu rapide pour KAP1 anticorps (ABIN645876)

Antigène: KAP1 (TRIM28) (Tripartite Motif Containing 28 (TRIM28))

Reactivité: Humain, Souris

Hôte: Chèvre

Conjugué: Cet anticorp KAP1 est non-conjugé

Application: Veuillez nous consulter SVP

Détail du produit anti-KAP1 anticorps

Specificité: The Goat anti-KAP1 / TRIM28 antibody detects protein derived from human recombinant protein and HepG2 lysate at various concentrations.

Réactivité croisée: Humain, Souris

Attributs du produit: Goat Anti-KAP1 / TRIM28

Immunogène: Peptide with sequence C-SSQELSGGPGDGP, from the C Terminus of the protein sequence according to NP_005753, was used as an immunogen.

Isotype: IgG

Information d'application

Restrictions: For Research Use only

Stockage

Reconstitution: Supplied as 100µg of purified antibody. 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Please avoid freeze-thaw cycles.

Stock: -20 °C

Détails sur KAP1

Antigène: KAP1 (TRIM28) (Tripartite Motif Containing 28 (TRIM28))

Autre désignation: KAP1 / TRIM28

Sujet: KAP1 is an 835 amino acid polypeptide that contains a RING finger, B boxes, and a PHD finger. KAP1 has been shown to form complexes with KRAB domain transcription factors and increase the efficiency with which they mediate repression. KAP1 has also been shown to directly interact with HP1 (heterochromatin protein 1) and KRAZ1 (Kruppel associated box containing zinc finger protein 1). KAP1 directly targets KRAZ1 to the foci of centromeric heterochromatin containing HP1alpha, helping to regulate transcriptional repression. Recent studies have shown that KAP1 mutants with the ability to bind KRAB but unable to bind HP1 leads to random distribution of KRAZ1 and strong transcriptional activation.

NCBI Accession: NP_005753

Pathways: Signalisation Hedgehog, Positive Regulation of Response to DNA Damage Stimulus