ATG5 anticorps

N° du produit ABIN650657

Il existe 1 publication pour ce produit. L’anticorps anti-ATG5 Polyclonal Lapin est utilisé pour la détection de ATG5 dans des échantillons de Humain. Il a été validé pour WB, IF et IHC (p).

Aperçu rapide pour ATG5 anticorps (ABIN650657)

Antigène: ATG5 (ATG5 Autophagy Related 5 (ATG5))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ATG5 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB12327

Détail du produit anti-ATG5 anticorps

Purification: This antibody is purified through a protein A column, followed by dialysis against PBS.

Immunogène: This ATG5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the full length of human ATG5.

Isotype: Ig Fraction

Information d'application

Indications d'application: IF: 1:200. WB: 1:1000. WB: 1:500. WB: 1:500. IHC-P: 1:10~50

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Date de péremption: 6 months

Références pour anticorps anti-ATG5 (ABIN650657)

Jaber, Dou, Chen, Catanzaro, Jiang, Ballou, Selinger, Ouyang, Lin, Zhang, Zong: "Class III PI3K Vps34 plays an essential role in autophagy and in heart and liver function." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 109, Issue 6, pp. 2003-8, (2012) (PubMed).

Détails sur ATG5

Antigène: ATG5 (ATG5 Autophagy Related 5 (ATG5))

Autre désignation: APG5

Sujet: Macroautophagy is the major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane bound autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane bound structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane bound autophagic bodies which are then degraded within the lysosome (or vacuole). APG5, required for autophagy, conjugates to ATG12 and associates with an isolation membrane to form a cup-shaped isolation membrane and autophagosome. The conjugate detaches from the membrane immediately before or after autophagosome formation is completed. APG5 may also play an important role in the apoptotic process, possibly within the modified cytoskeleton. Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity.

Poids moléculaire: 32447

ID gène: 9474

NCBI Accession: NP_004840

UniProt: Q9H1Y0

Pathways: Activation of Innate immune Response, Production of Molecular Mediator of Immune Response, Autophagy