Metabotropic Glutamate Receptor 3 anticorps (C-Term)

N° du produit ABIN652205

L’anticorps anti-Metabotropic Glutamate Receptor 3 Polyclonal Lapin est utilisé pour la détection de Metabotropic Glutamate Receptor 3 dans des échantillons de Humain. Il a été validé pour WB.

Aperçu rapide pour Metabotropic Glutamate Receptor 3 anticorps (C-Term) (ABIN652205)

Antigène: Metabotropic Glutamate Receptor 3 (GRM3) (Glutamate Receptor, Metabotropic 3 (GRM3))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Metabotropic Glutamate Receptor 3 est non-conjugé

Application: Western Blotting (WB)

Clone: RB4623

Détail du produit anti-Metabotropic Glutamate Receptor 3 anticorps

Épitope: AA 828-857, C-Term

Homologie: Pr

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This Metabotropic Glutamate Receptor 3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 828-857 amino acids from the C-terminal region of human Metabotropic Glutamate Receptor 3.

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Date de péremption: 6 months

Détails sur Metabotropic Glutamate Receptor 3

Antigène: Metabotropic Glutamate Receptor 3 (GRM3) (Glutamate Receptor, Metabotropic 3 (GRM3))

Autre désignation: Metabotropic Glutamate Receptor 3 (GPRC1C)

Sujet: L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 (also known as GPRC1C) while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. The activity of GRM3 is mediated by a G-protein that inhibits adenylate cyclase activity.

Poids moléculaire: 98879

ID gène: 2913

NCBI Accession: NP_000831

UniProt: Q14832

Pathways: cAMP Metabolic Process, Synaptic Membrane