PINK1 anticorps (C-Term)

N° du produit ABIN652208

L’anticorps Lapin Polyclonal anti-PINK1 a été validé pour WB. Il convient pour détecter PINK1 dans des échantillons de Humain et Souris. Il y a 1 publication disponible.

Aperçu rapide pour PINK1 anticorps (C-Term) (ABIN652208)

Antigène: PINK1 (PTEN Induced Putative Kinase 1 (PINK1))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PINK1 est non-conjugé

Application: Western Blotting (WB)

Clone: RB6517

Détail du produit anti-PINK1 anticorps

Épitope: AA 493-526, C-Term

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This Park6(PINK1) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 493-526 amino acids from the C-terminal region of human Park6(PINK1).

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Date de péremption: 6 months

Références pour anticorps anti-PINK1 (ABIN652208)

Berthier, Jiménez-Sáinz, Pulido: "PINK1 regulates histone H3 trimethylation and gene expression by interaction with the polycomb protein EED/WAIT1." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 110, Issue 36, pp. 14729-34, (2013) (PubMed).

Détails sur PINK1

Antigène: PINK1 (PTEN Induced Putative Kinase 1 (PINK1))

Autre désignation: Park6 (PINK1)

Sujet: Parkinson is the second most common neurodegenerative disease after Alzheimers. About 1 percent of people over the age of 65 and 3 percent of people over the age of 75 are affected by the disease. The mutation is the most common cause of Parkinson disease identified to date. Defects in PINK1 are the cause of autosomal recessive early-onset Parkinson's disease 6 (PARK6). Six novel pathogenic PINK1 mutations suggest that PINK1 may be the second most common causative gene next to parkin in parkinsonism with the recessive mode of inheritance. Strong evidence indicates that, although important in mendelian forms of Parkinson's disease (PD), PINK1 does not influence the cause of sporadic nonmendelian forms of PD.

Poids moléculaire: 62769

ID gène: 65018

NCBI Accession: NP_115785

UniProt: Q9BXM7

Pathways: Autophagy