GLS2 anticorps (AA 498-524)

N° du produit ABIN652216

Cet anticorps Lapin Polyclonal détecte spécifiquement GLS2 dans WB et IHC (p). Il présente une réactivité envers Humain et Souris et a été mentionné dans 1 publication.

Aperçu rapide pour GLS2 anticorps (AA 498-524) (ABIN652216)

Antigène: GLS2 (Glutaminase 2 (Liver, Mitochondrial) (GLS2))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GLS2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB20072

Détail du produit anti-GLS2 anticorps

Épitope: AA 498-524

Homologie: Rat

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This GLS2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 498-524 amino acids of human GLS2.

Isotype: IgG

Information d'application

Indications d'application: WB: 1:1000. IHC-P-Leica: 1:500

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Date de péremption: 6 months

Références pour anticorps anti-GLS2 (ABIN652216)

Shroff, Eberlin, Dang, Gouw, Gabay, Adam, Bellovin, Tran, Philbrick, Garcia-Ocana, Casey, Li, Dang, Zare, Felsher: "MYC oncogene overexpression drives renal cell carcinoma in a mouse model through glutamine metabolism." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 112, Issue 21, pp. 6539-44, (2015) (PubMed).

Détails sur GLS2

Antigène: GLS2 (Glutaminase 2 (Liver, Mitochondrial) (GLS2))

Autre désignation: GLS2

Sujet: The protein encoded by this gene is a mitochondrial phosphate-activated glutaminase that catalyzes the hydrolysis of glutamine to stoichiometric amounts of glutamate and ammonia. This protein is functionally similar to the kidney glutaminase but is a little smaller in size. Originally thought to be liver-specific, this protein has been found in other tissues as well. At least one transcribed pseudogene has been found for this gene. [provided by RefSeq].

Poids moléculaire: 66323

ID gène: 27165

NCBI Accession: NP_001267727, NP_037399

UniProt: Q9UI32

Pathways: Dicarboxylic Acid Transport, L'effet Warburg