RAD17 anticorps (AA 218-246)

N° du produit ABIN655646

L’anticorps Lapin Polyclonal anti-RAD17 a été validé pour WB et FACS. Il convient pour détecter RAD17 dans des échantillons de Humain.

Aperçu rapide pour RAD17 anticorps (AA 218-246) (ABIN655646)

Antigène: RAD17

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RAD17 est non-conjugé

Application: Western Blotting (WB), Flow Cytometry (FACS)

Clone: RB20035

Détail du produit anti-RAD17 anticorps

Épitope: AA 218-246

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This RAD17 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 218-246 amino acids from the Central region of human RAD17.

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000. FC: 1:10~50

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Date de péremption: 6 months

Détails sur RAD17

Antigène: RAD17

Autre désignation: RAD17

Sujet: The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein shares strong similarity with DNA replication factor C (RFC), and can form a complex with RFCs. This protein binds to chromatin prior to DNA damage and is phosphorylated by the checkpoint kinase ATR following damage. This protein recruits the RAD1-RAD9-HUS1 checkpoint protein complex onto chromatin after DNA damage, which may be required for its phosphorylation. The phosphorylation of this protein is required for the DNA-damage-induced cell cycle G2 arrest, and is thought to be a critical early event during checkpoint signaling in DNA-damaged cells. Eight alternatively spliced transcript variants of this gene, which encode four distinct proteins, have been reported. Two pseudogenes, located on chromosomes 7 and 13, have been identified.

Poids moléculaire: 77055

ID gène: 5884

NCBI Accession: NP_001265551, NP_002864, NP_579916, NP_579917, NP_579918, NP_579919, NP_579920, NP_579921, NP_579922

UniProt: O75943