DVL1 anticorps (AA 442-470)

N° du produit ABIN2845574

Cet anticorps Lapin Polyclonal détecte spécifiquement DVL1 dans WB, IF et IHC (p). Il présente une réactivité avec des échantillons de Humain et Souris.Il a été cité dans 1 publication.

Aperçu rapide pour DVL1 anticorps (AA 442-470) (ABIN2845574)

Antigène: DVL1 (Dishevelled Segment Polarity Protein 1 (DVL1))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DVL1 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB31716

Détail du produit anti-DVL1 anticorps

Épitope: AA 442-470

Homologie: Rat

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This DVL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 442-470 amino acids from the Central region of human DVL1.

Isotype: Ig Fraction

Information d'application

Indications d'application: IF: 1:10~50. IF: 1:25. WB: 1:1000. WB: 1:2000. WB: 1:1000. IHC-P: 1:10~50. IHC-P: 1:25

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Date de péremption: 6 months

Références pour anticorps anti-DVL1 (ABIN2845574)

Bunn, Daniel, Rösken, ONeill, Cameron-Christie, Morgan, Brunner, Lai, Kunst, Markie, Robertson: "Mutations in DVL1 cause an osteosclerotic form of Robinow syndrome." dans: American journal of human genetics, Vol. 96, Issue 4, pp. 623-30, (2015) (PubMed).

Détails sur DVL1

Antigène: DVL1 (Dishevelled Segment Polarity Protein 1 (DVL1))

Autre désignation: DVL1

Sujet: DVL1, the human homolog of the Drosophila dishevelled gene (dsh) encodes a cytoplasmic phosphoprotein that regulates cell proliferation, acting as a transducer molecule for developmental processes, including segmentation and neuroblast specification. DVL1 is a candidate gene for neuroblastomatous transformation. The Schwartz-Jampel syndrome and Charcot-Marie-Tooth disease type 2A have been mapped to the same region as DVL1. The phenotypes of these diseases may be consistent with defects which might be expected from aberrant expression of a DVL gene during development.

Poids moléculaire: 75187

ID gène: 1855

NCBI Accession: NP_004412

UniProt: O14640

Pathways: Signalisation WNT, Synaptic Membrane, Skeletal Muscle Fiber Development