GSAP anticorps (C-Term)

N° du produit ABIN656412

Cet anticorps anti-GSAP Polyclonal Lapin (Clone RB27384) (ABIN656412) détecte spécifiquement GSAP dans WB et IHC (p). L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour GSAP anticorps (C-Term) (ABIN656412)

Antigène: GSAP (PION) (Pigeon Homolog (PION))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GSAP est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB27384

Détail du produit anti-GSAP anticorps

Épitope: AA 537-565, C-Term

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This PION antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 537-565 amino acids from the C-terminal region of human PION.

Isotype: IgG

Information d'application

Indications d'application: WB: 1:1000. IHC-P: 1:10~50

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: PION Antibody (C-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.

Date de péremption: 6 months

Détails sur GSAP

Antigène: GSAP (PION) (Pigeon Homolog (PION))

Autre désignation: PION

Sujet: Accumulation of neurotoxic amyloid-beta is a major hallmark of Alzheimer disease (AD, MIM 104300). Formation of amyloid-beta is catalyzed by gamma-secretase (see PSEN1, MIM 104311), a protease with numerous substrates. PION, or GSAP, selectively increases amyloid-beta production through a mechanism involving its interaction with both gamma-secretase and its substrate, the amyloid-beta precursor protein (APP, MIM 104760) C-terminal fragment (APP-CTF) (He et al., 2010 [PubMed 20811458]).

Poids moléculaire: 97802

ID gène: 54103

NCBI Accession: NP_059135

UniProt: A4D1B5