CD40 anticorps

N° du produit ABIN6566508

L’anticorps Lapin Polyclonal anti-CD40 a été validé pour WB. Il convient pour détecter CD40 dans des échantillons de Humain, Souris et Rat.

Aperçu rapide pour CD40 anticorps (ABIN6566508)

Antigène: CD40

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CD40 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-CD40 anticorps

Purification: Affinity purification

Immunogène: Recombinant protein of human CD40

Isotype: IgG

Information d'application

Indications d'application: WB 1:500 - 1:2000

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur CD40

Antigène: CD40

Autre désignation: CD40

Sujet:

Synonyms: AI326936,B cell associated molecule CD40,B cell surface antigen CD40,B cell-associated molecule,B-cell surface antigen CD40,Bp50,CD 40,CD40,CD40 antigen (TNF receptor superfamily member 5),CD40 antigen,CD40 Molecule,CD40 Molecule,TNF receptor superfamily member 5,CD40 protein,CD40 type II isoform,CD40L receptor,CDw40,GP39,HIGM1,IGM,IMD3,MGC9013,Nerve growth factor receptor related B lymphocyte activation molecule,OTTHUMP00000031699,OTTHUMP00000031700,p50,T-BAM,TBAM,TNF receptor superfamily member 5,TNFRSF5,TNR5,TRAP,Tumor necrosis factor receptor superfamily,member 5,Tumor necrosis factor receptor superfamily member 5,Tumor necrosis factor receptor superfamily member 5 precursor,Tumor necrosis factor receptor superfamily,member 5,isoform CRA_a

Background: This gene is a member of the TNF-receptor superfamily. The encoded protein is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Mutations affecting this gene are the cause of autosomal recessive hyper-IgM immunodeficiency type 3 (HIGM3). Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

Poids moléculaire:

Observed_MW: 42kDa

Calculated_MW: 22kDa/30kDa

ID gène: 958

UniProt: P25942

Pathways: Signalisation NF-kappaB, Cellular Response to Molecule of Bacterial Origin, M Phase, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Cancer Immune Checkpoints