RPA1 anticorps

N° du produit ABIN6566683

Détail du produit anti-RPA1 anticorps

Antigène: RPA1 (Replication Protein A1, 70kDa (RPA1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RPA1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Purification: Affinity purification

Immunogène: Recombinant fusion protein of human RPA1 (NP_002936.1).

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000 IHC 1:50-1:100

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur RPA1

Antigène: RPA1 (Replication Protein A1, 70kDa (RPA1))

Autre désignation: RPA1 (RPA1 Produits)

Synonymes: anticorps HSSB, anticorps MST075, anticorps REPA1, anticorps RF-A, anticorps RP-A, anticorps RPA70, anticorps Cb1-727, anticorps wu:fi14b08, anticorps zgc:55337, anticorps zgc:77092, anticorps RPA1, anticorps hssb, anticorps mst075, anticorps repa1, anticorps rf-a, anticorps rp-a, anticorps rpa, anticorps rpa70, anticorps LOC100230990, anticorps 5031405K23Rik, anticorps 70kDa, anticorps AA589576, anticorps AW557552, anticorps Rpa, anticorps CG9633, anticorps D-RPA70, anticorps D-SSB, anticorps DRP-A, anticorps DmRPA, anticorps Dmel\\CG9633, anticorps RPA, anticorps RPA 70, anticorps RPA 70 kDa, anticorps RpA70, anticorps Rpa-70, anticorps Ssb-70, anticorps dRP-A, anticorps dmrpa1, anticorps i164, anticorps replication protein A1, anticorps replication protein A1, 70kDa, anticorps replication protein A1 L homeolog, anticorps Replication Protein A 70, anticorps RPA1, anticorps Rpa1, anticorps rpa1, anticorps rpa1.L, anticorps RpA-70

Sujet: This gene encodes the largest subunit of the heterotrimeric Replication Protein A (RPA) complex, which binds to single-stranded DNA (ssDNA), forming a nucleoprotein complex that plays an important role in DNA metabolism, being involved in DNA replication, repair, recombination, telomere maintenance, and co-ordinating the cellular response to DNA damage through activation of the ataxia telangiectasia and Rad3-related protein (ATR) kinase. The nucleoprotein complex protects the single-stranded DNA from nucleases, prevents formation of secondary structures that would interfere with repair, and co-ordinates the recruitment and departure of different genome maintenance factors. This subunit contains four oligonucleotide/oligosaccharide-binding (OB) domains, though the majority of ssDNA binding occurs in two of these domains. The heterotrimeric complex has two different modes of ssDNA binding, a low-affinity and high-affinity mode, determined by which ssDNA binding domains are utilized. The different binding modes differ in the length of DNA bound and in the proteins with which it interacts, thereby playing a role in regulating different genomic maintenance pathways.

Poids moléculaire:

Observed_MW: 70kDa

Calculated_MW: 68kDa

ID gène: 6117

UniProt: P27694

Pathways: Telomere Maintenance, Réparation de l'ADN, Mitotic G1-G1/S Phases, DNA Replication, Chromatin Binding, Synthesis of DNA