GEN1 anticorps

N° du produit ABIN6566734

Cet anticorps Lapin Polyclonal détecte spécifiquement GEN1 dans WB. Il présente une réactivité envers Humain et Souris.

Aperçu rapide pour GEN1 anticorps (ABIN6566734)

Antigène: GEN1 (Gen Endonuclease Homolog 1 (GEN1))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GEN1 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-GEN1 anticorps

Purification: Affinity purification

Immunogène: Recombinant protein of human GEN1

Isotype: IgG

Information d'application

Indications d'application: WB 1:500 - 1:2000

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur GEN1

Antigène: GEN1 (Gen Endonuclease Homolog 1 (GEN1))

Autre désignation: GEN1

Sujet:

Synonyms: DKFZp781F0986,Flap endonuclease GEN homolog 1,FLJ40869,GEN 1,Gen,Gen homolog 1 endonuclease (Drosophila),Gen homolog 1 endonuclease,GEN,GEN1

Background: This gene encodes a member of the Rad2/xeroderma pigmentosum group G nuclease family, whose members are characterized by N-terminal and internal xeroderma pigmentosum group G nuclease domains followed by helix-hairpin-helix domains and disordered C-terminal domains. The protein encoded by this gene is involved in resolution of Holliday junctions, which are intermediate four-way structures that covalently link DNA during homologous recombination and double-strand break repair. The protein resolves Holliday junctions by creating dual incisions across the junction to produce nicked duplex products that can be ligated. In addition, this protein has been found to localize to centrosomes where it has been implicated in regulation of centrosome integrity. Alternative splicing results in multiple transcript variants.

Poids moléculaire:

Observed_MW: 103kDa

Calculated_MW: 102kDa

ID gène: 348654

UniProt: Q17RS7

Pathways: Réparation de l'ADN