COPS7A anticorps (C-Term)

N° du produit ABIN656737

Cet anticorps Lapin Polyclonal détecte spécifiquement COPS7A dans WB et IHC (p). Il présente une réactivité envers Humain.

Aperçu rapide pour COPS7A anticorps (C-Term) (ABIN656737)

Antigène: COPS7A (COP9 Signalosome Complex Subunit 7a (COPS7A))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp COPS7A est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB32335

Détail du produit anti-COPS7A anticorps

Épitope: AA 237-266, C-Term

Homologie: M

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This COPS7A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 237-266 amino acids from the C-terminal region of human COPS7A.

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000. IHC-P: 1:10~50

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: COPS7A Antibody (C-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.

Date de péremption: 6 months

Détails sur COPS7A

Antigène: COPS7A (COP9 Signalosome Complex Subunit 7a (COPS7A))

Autre désignation: COPS7A

Sujet: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.

Poids moléculaire: 30277

ID gène: 50813

NCBI Accession: NP_001157565, NP_001157566, NP_001157567, NP_057403

UniProt: Q9UBW8

Pathways: Cycle Cellulaire