IL12RB1 anticorps

N° du produit ABIN6568961

L’anticorps anti-IL12RB1 Polyclonal Lapin est utilisé pour la détection de IL12RB1 dans des échantillons de Humain et Souris. Il a été validé pour IF.

Aperçu rapide pour IL12RB1 anticorps (ABIN6568961)

Antigène: IL12RB1 (Interleukin 12 Receptor beta 1 (IL12RB1))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp IL12RB1 est non-conjugé

Application: Immunofluorescence (IF)

Détail du produit anti-IL12RB1 anticorps

Purification: Affinity purification

Immunogène: Recombinant fusion protein of human IL12RB1 (NP_714912.1).

Isotype: IgG

Information d'application

Indications d'application: IF 1:10-1:100

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur IL12RB1

Antigène: IL12RB1 (Interleukin 12 Receptor beta 1 (IL12RB1))

Autre désignation: IL12RB1

Sujet: The protein encoded by this gene is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. This protein binds to interleukine 12 (IL12) with a low affinity, and is thought to be a part of IL12 receptor complex. This protein forms a disulfide-linked oligomer, which is required for its IL12 binding activity. The coexpression of this and IL12RB2 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. Mutations in this gene impair the development of interleukin-17-producing T lymphocytes and result in increased susceptibility to mycobacterial and Salmonella infections. Alternative splicing results in multiple transcript variants.

Poids moléculaire:

Observed_MW: 73kDa

Calculated_MW: 42kDa/72kDa/73kDa

ID gène: 3594

UniProt: P42701

Pathways: Signalistation JAK/STAT, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Activated T Cell Proliferation