NSD1 anticorps

N° du produit ABIN6572111

Cet anticorps Lapin Polyclonal détecte spécifiquement NSD1 dans WB. Il présente une réactivité envers Humain et Souris.

Aperçu rapide pour NSD1 anticorps (ABIN6572111)

Antigène: NSD1 (Nuclear Receptor Binding SET Domain Protein 1 (NSD1))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NSD1 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-NSD1 anticorps

Purification: Affinity purification

Immunogène: Recombinant protein of human NSD1

Isotype: IgG

Information d'application

Indications d'application: WB 1:500 - 1:1000

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur NSD1

Antigène: NSD1 (Nuclear Receptor Binding SET Domain Protein 1 (NSD1))

Autre désignation: NSD1

Sujet:

Synonyms: Nuclear Receptor Binding SET Domain Protein 1,Nuclear Receptor-Binding SET Domain-Containing Protein 1,Androgen Receptor-Associated Protein Of 267 KDa,Androgen Receptor Coactivator 267 KDa Protein,NR-Binding SET Domain-Containing Protein,Lysine N-Methyltransferase 3B,H3-K36-HMTase,H4-K20-HMTase,EC 2.1.1.43.

Background: This gene encodes a protein containing a SET domain, 2 LXXLL motifs, 3 nuclear translocation signals (NLSs), 4 plant homeodomain (PHD) finger regions, and a proline-rich region. The encoded protein enhances androgen receptor (AR) transactivation, and this enhancement can be increased further in the presence of other androgen receptor associated coregulators. This protein may act as a nucleus-localized, basic transcriptional factor and also as a bifunctional transcriptional regulator. Mutations of this gene have been associated with Sotos syndrome and Weaver syndrome. One version of childhood acute myeloid leukemia is the result of a cryptic translocation with the breakpoints occurring within nuclear receptor-binding Su-var, enhancer of zeste, and trithorax domain protein 1 on chromosome 5 and nucleoporin, 98-kd on chromosome 11. Two transcript variants encoding distinct isoforms have been identified for this gene.

Poids moléculaire:

Observed_MW: 297kDa

Calculated_MW: 267kDa/284kDa/296kDa

ID gène: 64324

UniProt: Q96L73