MMP2 anticorps (AA 303-331)

N° du produit ABIN657616

Cet anticorps Lapin Polyclonal détecte spécifiquement MMP2 dans WB. Il présente une réactivité envers Humain et a été mentionné dans 3+ publications.

Aperçu rapide pour MMP2 anticorps (AA 303-331) (ABIN657616)

Antigène: MMP2 (Matrix Metalloproteinase 2 (MMP2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MMP2 est non-conjugé

Application: Western Blotting (WB)

Clone: RB33605

Détail du produit anti-MMP2 anticorps

Épitope: AA 303-331

Homologie: C, M, Rb, Rat

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This MMP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 303-331 amino acids from the Central region of human MMP2.

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000. WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: MMP2 Antibody (Center) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.

Date de péremption: 6 months

Références pour anticorps anti-MMP2 (ABIN657616)

Chen, Liu, Gao, Hui, Yang, Zhang, Xu, Tian, Fan: "Preliminary evaluation for Bit1 as a potential biomarker for squamous cell carcinoma and adenocarcinoma of esophagus." dans: Tumour biology, Vol. 39, Issue 5, pp. 1010428317708270, (2017) (PubMed).

Dai, Duan, Duan, Zhou, He, Tu, Shen: "Down-regulation of TCF21 by hypermethylation induces cell proliferation, migration and invasion in colorectal cancer." dans: Biochemical and biophysical research communications, (2015) (PubMed).

Shi, Shang, Pan, Wang, Jiang, Hao, Zhang, Cai, Xu, Zhan, Wang: "Calreticulin promotes migration and invasion of esophageal cancer cells by upregulating neuropilin-1 expression via STAT5A." dans: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 20, Issue 23, pp. 6153-62, (2014) (PubMed).

Détails sur MMP2

Antigène: MMP2 (Matrix Metalloproteinase 2 (MMP2))

Autre désignation: MMP2

Sujet: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades type IV collagen, the major structural component of basement membranes. The enzyme plays a role in endometrial menstrual breakdown, regulation of vascularization and the inflammatory response. Mutations in this gene have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Two transcript variants encoding different isoforms have been found for this gene.

Poids moléculaire: 73882

ID gène: 4313

NCBI Accession: NP_001121363, NP_004521

UniProt: P08253

Pathways: Activation of Innate immune Response