Nemo-Like Kinase anticorps (C-Term)

N° du produit ABIN657850

Cet anticorps Lapin Polyclonal détecte spécifiquement Nemo-Like Kinase dans WB et IHC (p). Il présente une réactivité envers Humain et Souris.

Aperçu rapide pour Nemo-Like Kinase anticorps (C-Term) (ABIN657850)

Antigène: Nemo-Like Kinase (NLK)

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Nemo-Like Kinase est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB34651

Détail du produit anti-Nemo-Like Kinase anticorps

Épitope: AA 408-436, C-Term

Homologie: B, Rat

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This Mouse Nlk antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 408-436 amino acids from the C-terminal region of mouse Nlk.

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000. WB: 1:1000. IHC-P: 1:10~50

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Mouse Nlk Antibody (C-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.

Date de péremption: 6 months

Détails sur Nemo-Like Kinase

Antigène: Nemo-Like Kinase (NLK)

Autre désignation: Nlk

Sujet: Role in cell fate determination, required for differentiation of bone marrow stromal cells. Acts downstream of MAP3K7 and HIPK2 to negatively regulate the canonical Wnt/beta-catenin signaling pathway and the phosphorylation and destruction of the MYB transcription factor. May suppress a wide range of transcription factors by phosphorylation of the coactivator, CREBBP. Involved in TGFbeta-mediated mesoderm induction, acting downstream of MAP3K7/TAK1 to phosphorylate STAT3.

Poids moléculaire: 58313

ID gène: 100044468, 18099

NCBI Accession: NP_032728

UniProt: O54949

Pathways: Ubiquitin Proteasome Pathway