JMJD2D anticorps (AA 337-359)

N° du produit ABIN6579170

L’anticorps anti-JMJD2D Polyclonal Lapin est utilisé pour la détection de JMJD2D dans des échantillons de Humain. Il a été validé pour WB.

Aperçu rapide pour JMJD2D anticorps (AA 337-359) (ABIN6579170)

Antigène: JMJD2D (KDM4D) (Lysine (K)-Specific Demethylase 4D (KDM4D))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp JMJD2D est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-JMJD2D anticorps

Épitope: AA 337-359

Fonction: JMJD2D antibody (pAb)

Purification: Affinity Purified

Immunogène: This JMJD2D antibody was raised against a peptide corresponding to amino acids 337-359 of human JMJD2D.

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500 - 1:2,000 dilution

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified rabbit IgG in PBS with 30 % glycerol and 0.035 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions,Keep all reagents on ice when not in storage

Stock: -20 °C

Stockage commentaire: Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

Date de péremption: 24 months

Détails sur JMJD2D

Antigène: JMJD2D (KDM4D) (Lysine (K)-Specific Demethylase 4D (KDM4D))

Autre désignation: JMJD2D

Sujet: JMJD2D (KDM4D) is a histone demethylase located in the nucleus that specifically demethylates Lysine 9 of Histone H3, thereby playing a central role in the histone code. JMJD2D (KDM4D) demethylates both di- and trimethylated histone H3 Lys 9, while it has no activity on monomethylated residues. The demethylation reaction of the Lys residue generates formaldehyde and succinate as a by product. In addition, JMJD2D forms a complex with the ligand-bound form of the Androgen Receptor (AR) and, through this interaction, activates AR expression. Overexpression of AR is associated with prostate cancer, suggesting that, via its ability to upregulate AR, JMJD2D (KDM4D) may be involved in carcinogenesis.

Poids moléculaire: 58 kDa

ID gène: 55693

NCBI Accession: NP_060509

Pathways: L'effet Warburg