Perforin 1 anticorps (AA 451-500)

N° du produit ABIN6579662

Cet anticorps anti-Perforin 1 Polyclonal Lapin (ABIN6579662) détecte spécifiquement Perforin 1 dans WB, IHC et ELISA. L’anticorps est réactif avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour Perforin 1 anticorps (AA 451-500) (ABIN6579662)

Antigène: Perforin 1 (PRF1) (Perforin 1 (Pore Forming Protein) (PRF1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Perforin 1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Détail du produit anti-Perforin 1 anticorps

Épitope: AA 451-500

Fonction: Perforin 1 Antibody

Specificité: Perforin 1 Polyclonal Antibody detects endogenous levels of Perforin 1

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogène: The antiserum was produced against synthesized peptide derived from the C-terminal region of human PRF1. AA range:451-500

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-2000, IHC 1:50-200, ELISA 1:10000-20000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C/1 year

Date de péremption: 12 months

Détails sur Perforin 1

Antigène: Perforin 1 (PRF1) (Perforin 1 (Pore Forming Protein) (PRF1))

Autre désignation: PRF1

Sujet:

Synonyms: Perforin-1 (P1) (Cytolysin) (Lymphocyte pore-forming protein) (PFP)

Background: The protein encoded by this gene has structural and functional similarities to complement component 9 (C9). Like C9, this protein creates transmembrane tubules and is capable of lysing non-specifically a variety of target cells. This protein is one of the main cytolytic proteins of cytolytic granules, and it is known to be a key effector molecule for T-cell- and natural killer-cell-mediated cytolysis. Defects in this gene cause familial hemophagocytic lymphohistiocytosis type 2 (HPLH2), a rare and lethal autosomal recessive disorder of early childhood. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008],

Gene Name: PRF1

Protein Name: Perforin 1

Poids moléculaire: 61 kDa

ID gène: 5551

OMIM: 170280

UniProt: P14222

Pathways: Apoptose, Caspase Cascade in Apoptosis