uPAR uPA Receptor anticorps

N° du produit ABIN6654046

L’anticorps Lapin Polyclonal anti- a été validé pour WB et FACS. Il convient pour détecter dans des échantillons de Humain, Souris et Rat.

Aperçu rapide pour uPAR uPA Receptor anticorps (ABIN6654046)

Antigène: uPAR uPA Receptor

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Inconjugué

Application: Western Blotting (WB), Flow Cytometry (FACS)

Détail du produit

Purification: Antigen affinity purified

Immunogène: Amino acids TKSGCNHPDLDVQYRS were used as the immunogen for the uPAR antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the uPAR antibody should be determined by the researcher.\. Western blot: 0.5-1 μg/mL,FACS: 1-3 μg/10^6 cells

Restrictions: For Research Use only

Stockage

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: -20 °C

Stockage commentaire: After reconstitution, the uPAR antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Détail du antigène

Antigène: uPAR uPA Receptor

Autre désignation: uPAR / uPA Receptor

Sujet: PLAUR (PLASMINOGEN ACTIVATOR RECEPTOR, UROKINASE-TYPE), also known as UPAR or CD87, is multidomain glycoprotein tethered to the cell membrane with a glycosylphosphotidylinositol (GPI) anchor. PLAUR consists of three different domains of the Ly-6/uPAR/alpha-neurotoxin family. PLAUR is originally identified as a saturable binding site for urokinase on the cell surface. And the gene plays an important role in many normal as well as pathologic processes. The PLAUR gene is localized to 19q13.31. PLAUR is a part of the plasminogen activation system, which in the healthy body is involved in tissue reorganization events such as mammary gland involution and wound healing. PLAUR binds urokinase and thus restricts plasminogen activation to the immediate vicinity of the cell membrane. Thus it seems to be an important player in the regulation of this process. In human coronary artery vascular smooth muscle cells, UPA stimulates cell migration via a UPAR signaling complex containing TYK2 and phosphatidylinositol 3-kinase.

UniProt: Q03405