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ALK anticorps

ALK Reactivité: Humain IHC (p) Hôte: Lapin Monoclonal ATKR-2R unconjugated
N° du produit ABIN6654206
  • Antigène Voir toutes ALK Anticorps
    ALK (Anaplastic Lymphoma Receptor tyrosine Kinase (ALK))
    Reactivité
    • 17
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 17
    • 2
    Lapin
    Clonalité
    • 16
    • 3
    Monoclonal
    Conjugué
    • 16
    • 1
    • 1
    • 1
    Cet anticorp ALK est non-conjugé
    Application
    • 9
    • 8
    • 6
    • 6
    • 2
    • 1
    • 1
    Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Purification
    Purified
    Pureté
    Protein A affinity
    Immunogène
    Recombinant full length human protein was used as the immunogen for this recombinant ALK antibody.
    Clone
    ATKR-2R
    Isotype
    IgG kappa
    Top Product
    Discover our top product ALK Anticorps primaire
  • Indications d'application
    Optimal dilution of the recombinant ALK antibody should be determined by the researcher.
    1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.\. IHC (FFPE): 1-2 μg/mL for 30 min at RT,Prediluted IHC only format: incubate for 30 min at RT (1)
    Restrictions
    For Research Use only
  • Buffer
    0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    Store the recombinant ALK antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).
  • Antigène
    ALK (Anaplastic Lymphoma Receptor tyrosine Kinase (ALK))
    Autre désignation
    ALK / Anaplastic Lymphoma Kinase (ALK Produits)
    Synonymes
    anticorps Tcrz, anticorps CD246, anticorps NBLST3, anticorps ALK, anticorps anaplastic lymphoma kinase, anticorps anaplastic lymphoma receptor tyrosine kinase, anticorps ALK receptor tyrosine kinase, anticorps Alk, anticorps ALK
    Sujet
    Neuronal receptor tyrosine kinase that is essentially and transiently expressed in specific regions of the central and peripheral nervous systems and plays an important role in the genesis and differentiation of the nervous system. Transduces signals from ligands at the cell surface, through specific activation of the mitogen-activated protein kinase (MAPK) pathway. Phosphorylates almost exclusively at the first tyrosine of the Y-x-x-x-Y-Y motif. Following activation by ligand, ALK induces tyrosine phosphorylation of CBL, FRS2, IRS1 and SHC1, as well as of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1. Acts as a receptor for ligands pleiotrophin (PTN), a secreted growth factor, and midkine (MDK), a PTN-related factor, thus participating in PTN and MDK signal transduction. PTN-binding induces MAPK pathway activation, which is important for the anti-apoptotic signaling of PTN and regulation of cell proliferation. MDK-binding induces phosphorylation of the ALK target insulin receptor substrate (IRS1), activates mitogen-activated protein kinases (MAPKs) and PI3-kinase, resulting also in cell proliferation induction. Drives NF-kappa-B activation, probably through IRS1 and the activation of the AKT serine/threonine kinase. Recruitment of IRS1 to activated ALK and the activation of NF-kappa-B are essential for the autocrine growth and survival signaling of MDK. [UniProt]
    Pathways
    Signalisation RTK
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