Desmin anticorps

N° du produit ABIN6654512

Cet anticorps anti-Desmin est un anticorps Lapin Monoclonal détectant Desmin dans IHC (p). Adapté pour Humain.

Aperçu rapide pour Desmin anticorps (ABIN6654512)

Antigène: Desmin (DES)

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp Desmin est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: DES-2960R

Détail du produit anti-Desmin anticorps

Purification: Purified

Pureté: Protein A affinity chromatography

Immunogène: Recombinant human protein was used as the immunogen for the recombinant Desmin antibody.

Isotype: IgG kappa

Information d'application

Indications d'application: Optimal dilution of the recombinant Desmin antibody should be determined by the researcher.

1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.\. Immunohistochemistry (FFPE): 1-2 μg/mL for 30 min at RT,Prediluted IHC only format: incubate for 30 min at RT (1)

Restrictions: For Research Use only

Stockage

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Agent conservateur: Azide free

Stock: 4 °C,-20 °C

Stockage commentaire: Store the recombinant Desmin antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).

Détails sur Desmin

Antigène: Desmin (DES)

Autre désignation: Desmin

Sujet: Cytoskeletal intermediate filaments (IFs) constitute a diverse group of proteins that are expressed in a highly tissue-specific manner. IFs are constructed from two-chain alpha-helical coiled-coil molecules arranged on an imperfect helical lattice, and have been widely used as markers for distinguishing individual cell types within a tissue and identifying the origins of metastatic tumors. Vimentin is an IF general marker of cells originating in the mesenchyme. Vimentin and Desmin, a related class III IF, are both expressed during skeletal muscle development. Desmin, a 469 amino acid protein found near the Z line in sarcomeres, is expressed more frequently in adult differentiated state tissues. Anti-desmin detects cells of normal smooth, skeletal, and cardiac muscles. Antibody reacts with leiomyomas, leiomyosarcoma, rhabdomyomas, rhabdomyosarcoma, and perivascular cells of glomus tumors of the skin.