MUC3A anticorps

N° du produit ABIN6654972

Cet anticorps Lapin Monoclonal détecte spécifiquement MUC3A dans IHC (p). Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour MUC3A anticorps (ABIN6654972)

Antigène: MUC3A (Mucin 3A, Cell Surface Associated (MUC3A))

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp MUC3A est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: MUC3-2992R

Détail du produit anti-MUC3A anticorps

Purification: Purified

Pureté: Protein A affinity chromatography

Immunogène: Amino acids (C-HSTPSFTSSITTTETTSHSTPSFTSSITTTETTS) which contains two of the MUC3 tandem repeats was used as the immunogen for the MUC3 antibody.

Isotype: IgG kappa

Information d'application

Indications d'application: Optimal dilution of the recombinant MUC3 antibody should be determined by the researcher.

1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.\. Immunohistochemistry (FFPE): 1-2 μg/mL for 30 min at RT,Prediluted IHC only format: incubate for 30 min at RT (1)

Restrictions: For Research Use only

Stockage

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Agent conservateur: Azide free

Stock: 4 °C,-20 °C

Stockage commentaire: Store the recombinant MUC3 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).

Détails sur MUC3A

Antigène: MUC3A (Mucin 3A, Cell Surface Associated (MUC3A))

Autre désignation: MUC3

Sujet: It recognizes a protein of HMW, identified as mucin 3 glycoprotein (MUC3). Its epitope localizes between aa SITTTE. This MAb shows no cross-reaction with human milk fat globule membranes, MUC1, or MUC2. MUC3 is distributed in colon and rectum, and is also present to a lesser extent in breast, lung and salivary gland tissues. The Mucins are a family of highly glycosylated, secreted proteins with a basic structure consisting of a variable number of tandem repeats (VNTRs) encoded by 60 base pairs (Mucin 1), 69 base pairs (Mucin 2) and 51 base pairs (Mucin 3). The number of repeats is highly polymorphic and varies among different alleles. Mucin 1 proteins are expressed as type I membrane proteins in addition to secreted forms. Mucin 1 is aberrantly expressed in epithelial tumors including breast carcinomas. Mucin 2 coats the epithelia of the intestines and airways and is associated with colonic tumors. Mucin 3 is a major component of various mucus gels and is broadly expressed in normal and tumor cells.