TRF2 anticorps

N° du produit ABIN6655376

N° du produit (Fournisseur): 200-301-i34

Cet anticorps anti-TRF2 est un anticorps Souris Monoclonal détectant TRF2 dans WB, ELISA, IHC, IP, IF, ChIP, FACS et FM. Adapté pour Humain.

Aperçu rapide pour TRF2 anticorps (ABIN6655376)

Antigène: TRF2 (TERF2) (Telomeric Repeat Binding Factor 2 (TERF2))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp TRF2 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunofluorescence (IF), Chromatin Immunoprecipitation (ChIP), Flow Cytometry (FACS), Fluorescence Microscopy (FM)

Clone: 4A794-15

Détail du produit anti-TRF2 anticorps

N° du produit (Fournisseur): 200-301-i34

Fournisseur: Rockland

Fonction: TRF2 Antibody

Réactivité croisée (Details): A BLAST analysis was used to suggest cross-reactivity with Anti-TRF2 from Human, Mouse, Muntjac (deer), and rat based on 100 % homology with the immunizing sequence.

Purification: Anti-TRF2 Antibody was purified by Protein G chromatography.

Immunogène: TRF2 Antibody was produced in mice by repeated immunizations with a full-length TRF2 human protein.

Isotype: IgG1 kappa

Information d'application

Indications d'application:

ChIP_Dilution: User Optimized

Immunoprecipitation_Dilution: 2 μg/10^6 cells

ELISA_Dilution: 2 μg/mL

Immunohistochemistry_Dilution: 5 μg/mL

Flow_Cytometry_Dilution: User Optimized

IF_Microscopy_Dilution: User Optimized

Western_Blot_Dilution: 2-4 μg/mL

Commentaires:

Anti-TRF2 Antibody is tested for use in WB, ChIP, ELISA, Flow, ICC/IF, IHC, IHC-Fr, IHC-P, and IP. Expect a band approximately 55.6 kDa on specific lysates. Specific conditions for reactivity should be optimized by the end user.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer:

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

Stabilizer: 0.05 % BSA

Preservative: 0.05 % (w/v) Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.

Date de péremption: 12 months

Détails sur TRF2

Antigène: TRF2 (TERF2) (Telomeric Repeat Binding Factor 2 (TERF2))

Autre désignation: TERF2

Sujet:

Synonyms: TRBF2, TRF2, Telomeric repeat-binding factor 2, TTAGGG repeat-binding factor 2, Telomeric DNA-binding protein

Background: TRF2 antibody detects human, mouse, deer and rat TRF2. TRF2 is an ubiquitously expressed protein that is implicated in the control of telomere length. TRF2, like TRF1, contains a Myb-related DNA binding motif. It binds to duplex TTAGGG repeats and is localized to all human telomeres in metaphase chromosomes. TRF2 is thought to protect chromosome ends by maintaining the correct structure at telomere termini. The use of mutant forms of TRF2 has implicated a role for TRF2 in the prevention of senescence in primary human cells. Recently, it has been shown that inhibition of TRF2 resulted in apoptosis in a subset of mammalian cell types. Anti TRF2 antibody is ideal for investigators involved in apoptosis and chromatin research.

Gene Name: TERF2

ID gène: 7014

NCBI Accession: NP_005643

UniProt: Q15554

Pathways: Cycle Cellulaire, Telomere Maintenance