LSD1 anticorps

N° du produit ABIN6655416

N° du produit (Fournisseur): 200-401-w52

Cet anticorps Lapin Polyclonal détecte spécifiquement LSD1 dans WB et ChIP. Il présente une réactivité envers Humain.

Aperçu rapide pour LSD1 anticorps (ABIN6655416)

Antigène: LSD1 (KDM1A) (Lysine (K)-Specific Demethylase 1A (KDM1A))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp LSD1 est non-conjugé

Application: Western Blotting (WB), Chromatin Immunoprecipitation (ChIP)

Détail du produit anti-LSD1 anticorps

N° du produit (Fournisseur): 200-401-w52

Fournisseur: Rockland

Fonction: LSD1 Antibody

Réactivité croisée (Details): Cross reactivity with other species was not tested.

Purification: Anti-LSD1 Antibody was purified by Protein G chromatography.

Stérilité: Sterile filtered

Immunogène: Anti-LSD1 Antibody was produced in rabbits by repeated immunizations with a full length recombinant protein of human LSD1.

Isotype: IgG

Information d'application

Indications d'application:

ChIP_Dilution: 3 μg per IP

Western_Blot_Dilution: 1:1,000

Commentaires:

Anti-LSD1 Antibody is tested for Chromatin Immunoprecipitation and Western Blots. Specific conditions for reactivity should be optimized by the end user. Expect a band approximately 110 kDa in the appropriate cell lysate or extract.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer:

Buffer: 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride, pH 7.2

Stabilizer: None

Preservative: 0.05 % (w/v) Sodium Azide and 0.05 % ProClin 300

Agent conservateur: ProClin, Sodium azide

Précaution d'utilisation: This product contains Sodium azide and ProClin: POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.

Date de péremption: 12 months

Détails sur LSD1

Antigène: LSD1 (KDM1A) (Lysine (K)-Specific Demethylase 1A (KDM1A))

Autre désignation: LSD1

Sujet:

Synonyms: Lysine-specific histone demethylase 1A, BRAF35-HDAC complex protein BHC110, Flavin-containing amine oxidase domain-containing protein 2, AOF2, KDM1

Background: LSD1 (lysine specific demethylase 1) is a component of the histone demethylase complex that uses FAD as a prosthetic goup. LSD1 may have a dual effect on gene transcription. As it demethylates the mono- and dimethylated 'Lys-4' of histone H3, which are associated with transcriptional activation, LSD1 can act as a repressor of gene expression. However, LSD1 is also capable of demethylating 'Lys-9' of histone H3, a specific tag for epigenetic transcriptional repression, thereby leading to activation of androgen receptor target genes. LSD1 therefore is ideal for research in different processes such as Stem and Cancer Cell Biology, Embryonic Development, Epigenetics and Cell Differentiation and Proliferation.

Gene Name: KDM1A

ID gène: 23028

NCBI Accession: NP_001009999

UniProt: O60341

Pathways: Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, Negative Regulation of intrinsic apoptotic Signaling, L'effet Warburg