RIPK3 anticorps (C-Term)
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- Antigène Voir toutes RIPK3 Anticorps
- RIPK3 (Receptor-Interacting serine-threonine Kinase 3 (RIPK3))
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Épitope
- C-Term
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp RIPK3 est non-conjugé
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Application
- Western Blotting (WB), Immunohistochemistry (IHC)
- Purification
- Anti-Receptor-interacting serine-threonine kinase 3 Antibody was purified by affinity chromatography. A BLAST analysis was used to suggest cross-reactivity with Anti-Receptor-interacting serine-threonine kinase 3 from human and chimpanzee based on 100% homology with the immunizing sequence. Cross-reactivity with Anti-Receptor-interacting serine-threonine kinase 3 from other sources has not been determined.
- Immunogène
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Immunogen: Receptor-interacting serine-threonine kinase 3 Antibody was produced from whole rabbit serum prepared by repeated immunizations with a peptide corresponding to amino acids near the c-terminus of human Receptor-interacting serine/threonine-protein kinase 3.
Immunogen Type: Peptide
- Isotype
- IgG
- Top Product
- Discover our top product RIPK3 Anticorps primaire
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- Indications d'application
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Immunohistochemistry Dilution: 10 μg/mL
Application Note: Anti-Receptor-interacting serine-threonine kinase 3 antibody is suitable for use in IHC (p) and WB. Expect a band approximately 56 kDa (isoform 1) and 27 kDa (isoform 2) on specific lysates. Specific conditions for reactivity should be optimized by the end user.
Western Blot Dilution: 3-7 μg/mL
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
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Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
Stabilizer: 0.05 % BSA
0.05 % (w/v) Sodium Azide - Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- RT,4 °C,-20 °C
- Stockage commentaire
- Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
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- Antigène
- RIPK3 (Receptor-Interacting serine-threonine Kinase 3 (RIPK3))
- Autre désignation
- Receptor-interacting serine-threonine kinase 3 (RIPK3 Produits)
- Synonymes
- anticorps RIPK3, anticorps RIP3, anticorps 2610528K09Rik, anticorps AW107945, anticorps Rip3, anticorps Hcyp2, anticorps receptor interacting serine/threonine kinase 3, anticorps receptor interacting serine/threonine kinase 3 S homeolog, anticorps receptor-interacting serine-threonine kinase 3, anticorps RIPK3, anticorps ripk3.S, anticorps Ripk3
- Sujet
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Synonyms: RIP3, Receptor-interacting serine/threonine-protein kinase 3, 2.7.11.1, RIP-like protein kinase 3, Receptor-interacting protein 3
Background: Anti-Receptor-interacting serine-threonine kinase 3 antibody detects human RIP3. RIP3 is a novel member of RIP Ser/Thr kinase family. It is a potent inducer of apoptosis and is an important component of TNFR1 signaling complex. RIP3 consists of an N-terminal RIP-like-Kinase domain and a unique, non-homologous C-terminus responsible for caspase activation and apoptosis induction. RIP3 is expressed in multiple tissues including hematopoietic cells and plays a functional role in the regulation of apoptosis and NF-kB signaling. It is recruited to the TNFR1 signaling complex in a RIP-dependant manner where it induces apoptosis by activating caspases and/or inhibiting TNFR1-induced NF-kB activation. RIP3 negatively regulates the TLR3-Trif mediated NF-kB signaling pathway by competing with the binding of Trif to RIP1. The human RIP3 gene is localized in the chromosomal region 14q11.2. Anti-Receptor-interacting serine-threonine kinase 3 Antibody is ideal for investigators involved in apoptosis and NFkappaB research.
Gene Name: RIPK3
- ID gène
- 11035
- NCBI Accession
- NP_006862
- UniProt
- Q9Y572
- Pathways
- Activation of Innate immune Response, Toll-Like Receptors Cascades
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