GPBAR1 anticorps (C-Term)

N° du produit ABIN6657009

N° du produit (Fournisseur): 100-401-h59

Cet anticorps Lapin Polyclonal détecte spécifiquement GPBAR1 dans WB. Il présente une réactivité envers Humain.

Aperçu rapide pour GPBAR1 anticorps (C-Term) (ABIN6657009)

Antigène: GPBAR1 (G Protein-Coupled Bile Acid Receptor 1 (GPBAR1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GPBAR1 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-GPBAR1 anticorps

Épitope: C-Term

N° du produit (Fournisseur): 100-401-h59

Fournisseur: Rockland

Fonction: BG37 Antibody

Réactivité croisée (Details): A BLAST analysis was used to suggest cross-reactivity with BG37 from human and mouse based on 100 % homology with the immunizing sequence.

Purification: Anti-BG37 Antibody is sera.

Immunogène: BG37 Antibody was produced from whole rabbit serum which was prepared by repeated immunizations with the amino acid portion of human BG37 near the C-terminus of the chain .

Isotype: IgG

Information d'application

Indications d'application: Optional[Neutralization_Dilution]: 1:1000-1:5000

Commentaires:

Anti-BG37 Antibody has been tested in WB. Expect a band approximately 37kDa on specific lysates. Specific conditions for reactivity should be optimized by the end user.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Optional[Buffer]: 50 % (v/v) Glycerol ,0.05 % (w/v) Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.

Date de péremption: 12 months

Détails sur GPBAR1

Antigène: GPBAR1 (G Protein-Coupled Bile Acid Receptor 1 (GPBAR1))

Autre désignation: BG37

Sujet:

Synonyms: TGR5, G-protein coupled bile acid receptor 1, G-protein coupled receptor GPCR19, hGPCR19, Membrane-type receptor for bile acids, M-BAR, hBG37, BG37

Background: Anti-BG37 TGR5 Antibody detects human BG37tgr5. BG37 is a 330 amino acid novel enzyme with seven transmembrane domains. It belongs to the G protein-coupled receptor (GPCR) superfamily and functions as a cell surface receptor for bile acids. Cells expressing BG37 when treated with bile acids induce the production of intracellular cAMP, activate the MAP kinase signaling pathway, leads to the internalization of the receptor and regulates proglucagon gene expression in enteroendocrine cells. The receptor is implicated in the suppression of macrophage functions and regulation of energy homeostasis by bile acids that can be targeted to improve metabolic control. It is known to be ubiquitously expressed in most of the tissues. Anti-BG37 TGR5 Antibody is ideal for investigators involved in kinase, phosphatase, and NFkappaB research.

Gene Name: GPBAR1

ID gène: 151306

NCBI Accession: NP_001070659

UniProt: Q8TDU6

Pathways: Signalisation WNT, Hormone Transport, Sensory Perception of Sound