GPBAR1 anticorps (C-Term)

N° du produit ABIN6657009

Détail du produit anti-GPBAR1 anticorps

Antigène: GPBAR1 (G Protein-Coupled Bile Acid Receptor 1 (GPBAR1))

Épitope: C-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GPBAR1 est non-conjugé

Application: Western Blotting (WB)

Réactivité croisée: Humain, Souris, Rat (Rattus)

Purification: Anti-BG37 Antibody is sera. A BLAST analysis was used to suggest cross-reactivity with BG37 from human and mouse based on 100% homology with the immunizing sequence. Predicted reactivity with cow. Cross-reactivity with BG37 from other sources has not been determined.

Immunogène:

Immunogen: BG37 Antibody was produced from whole rabbit serum which was prepared by repeated immunizations with the amino acid portion of human BG37 near the C-terminus of the chain .

Immunogen Type: Peptide

Information d'application

Indications d'application:

Application Note: Anti-BG37 Antibody is suitable for use in WB. Expect a band approximately 37 kDa on specific lysates. Specific conditions for reactivity should be optimized by the end user.

Western Blot Dilution: 1:1000-1:5000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: 50 % (v/v) Glycerol0.05 % (w/v) Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: RT,4 °C,-20 °C

Stockage commentaire: Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.

Détails sur GPBAR1

Antigène: GPBAR1 (G Protein-Coupled Bile Acid Receptor 1 (GPBAR1))

Autre désignation: BG37 (GPBAR1 Produits)

Synonymes: anticorps BG37, anticorps GPCR19, anticorps GPR131, anticorps M-BAR, anticorps TGR5, anticorps Tgr5, anticorps MGC84403, anticorps GPBAR1, anticorps Gpbar1, anticorps GPCR, anticorps G protein-coupled bile acid receptor 1, anticorps G protein-coupled bile acid receptor 1 S homeolog, anticorps GPBAR1, anticorps Gpbar1, anticorps gpbar1.S

Sujet:

Synonyms: TGR5, G-protein coupled bile acid receptor 1, G-protein coupled receptor GPCR19, hGPCR19, Membrane-type receptor for bile acids, M-BAR, hBG37, BG37

Background: Anti-BG37 TGR5 Antibody detects human BG37tgr5. BG37 is a 330 amino acid novel enzyme with seven transmembrane domains. It belongs to the G protein-coupled receptor (GPCR) superfamily and functions as a cell surface receptor for bile acids. Cells expressing BG37 when treated with bile acids induce the production of intracellular cAMP, activate the MAP kinase signaling pathway, leads to the internalization of the receptor and regulates proglucagon gene expression in enteroendocrine cells. The receptor is implicated in the suppression of macrophage functions and regulation of energy homeostasis by bile acids that can be targeted to improve metabolic control. It is known to be ubiquitously expressed in most of the tissues. Anti-BG37 TGR5 Antibody is ideal for investigators involved in kinase, phosphatase, and NFkappaB research.

Gene Name: GPBAR1

ID gène: 151306

NCBI Accession: NP_001070659

UniProt: Q8TDU6

Pathways: Signalisation WNT, Hormone Transport, Sensory Perception of Sound