CDK5 anticorps

N° du produit ABIN6658103

N° du produit (Fournisseur): 200-301-163

Cet anticorps anti-CDK5 est un anticorps Souris Monoclonal détectant CDK5 dans WB et IHC. Adapté pour Rat. Ce Primary Antibody a été cité dans 4+ publications.

Aperçu rapide pour CDK5 anticorps (ABIN6658103)

Antigène: CDK5 (Cyclin-Dependent Kinase 5 (CDK5))

Reactivité: Rat

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CDK5 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Clone: 1H3

Détail du produit anti-CDK5 anticorps

N° du produit (Fournisseur): 200-301-163

Fournisseur: Rockland

Fonction: Cdk5 Antibody

Réactivité croisée (Details): Anti-CDK5 Antibody is directed against rat CDK5 protein.

Purification: The antibody was Protein G purified from cell culture supernatant by chromatography.

Immunogène: Anti-CDK5 Antibody was produced by repeated immunizations with purified rat Cdk5

Isotype: IgG1

Information d'application

Indications d'application:

Immunohistochemistry_Dilution: 1:500

Western_Blot_Dilution: 1:1000

Commentaires:

Suggested Applications: IF
Anti-CDK5 (Mouse) has been tested for use in Western Blotting and is excellent for use in IHC. Specific conditions for reactivity should be optimized by the end user. Expect a band of ~28kDa in size in rat striatal lysates by Western Blotting. Anti-CDK5 antibodies also work well for immunocytochemistry using primary cultured rat neurons and for immunohistochemistry on mouse brain tissue.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer:

Buffer: 0.01 M HEPES, 0.15 M Sodium Chloride, pH 7.5

Stabilizer: 0.1 mg/mL Bovine Serum Albumin (BSA) - IgG and Protease free, 50 % (v/v) Glycerol

Stock: 4 °C,-20 °C

Stockage commentaire: Store vial at -20° C prior to opening.  This product is stable at 4° C as an undiluted liquid.  For extended storage, aliquot contents and freeze at -20° C or below.  Avoid cycles of freezing and thawing. Dilute only prior to immediate use.

Date de péremption: 12 months

Références pour anticorps anti-CDK5 (ABIN6658103)

Gupta, Herring, Kumar, Telange, Garcia-Buntley, Caceres, Colantonio, Williams, Kurup, Carter, Lin, Chen, Rose, Jaskula-Sztul, Mukhtar, Reddy, Bibb: "Faulty Metabolism: A Potential Instigator of an Aggressive Phenotype in Cdk5-dependent Medullary Thyroid Carcinoma." dans: bioRxiv : the preprint server for biology, (2023) (PubMed).

Thomas, Hernandez, Benavides, Li, Tan, Umfress, Plattner, Chakraborti, Pozzo-Miller, Taylor, Bibb: "Integrated regulation of PKA by fast and slow neurotransmission in the nucleus accumbens controls plasticity and stress responses." dans: The Journal of biological chemistry, Vol. 298, Issue 8, pp. 102245, (2022) (PubMed).

Gupta, Strange, Telange, Guo, Hatch, Sobh, Elie, Carter, Totenhagen, Tan, Sonawane, Neuzil, Natarajan, Ovens, Oakhill, Wiederhold, Pacak, Ghayee, Meijer, Reddy, Bibb: "Genetic impairment of succinate metabolism disrupts bioenergetic sensing in adrenal neuroendocrine cancer." dans: Cell reports, Vol. 40, Issue 7, pp. 111218, (2022) (PubMed).

Carter, Kumar, Herring, Tan, Guenter, Telange, Howse, Viol, McCaw, Bickerton, Gupta, Gillardon, Woltering, Dhall, Totenhagen, Banerjee, Kurian, Reddy, Chen, Schrader, Bart Rose, Mukhtar, Bibb: "Cdk5 drives formation of heterogeneous pancreatic neuroendocrine tumors." dans: Oncogenesis, Vol. 10, Issue 12, pp. 83, (2021) (PubMed).

Détails sur CDK5

Antigène: CDK5 (Cyclin-Dependent Kinase 5 (CDK5))

Autre désignation: CDK5

Sujet:

Synonyms: mouse anti-cdk5 antibody, cdk, mouse anti-Cyclin-dependent kinase 5, Cell division protein kinase 5, Serine/threonine-protein kinase PSSALRE, Tau protein kinase II catalytic subunit

Background: CDK5 antibody recognizes the neuronal protein kinase Cdk5 which is implicated in a vast array of normal neuronal functions including regulation of neurotransmitter synthesis, the presynaptic vesicle cycle, neurotransmitter receptor trafficking and dopamine neurotransmission. At the same time Cdk5 has been implicated in a plethora of neurological and neuropsychiatric disorders including Alzheimer's, Parkinson's, Huntington's, epilepsy, schizophrenia, and drug addiction. Detection of Cdk5 in normal samples as well as tissue undergoing neurodegeneration may advance studies in these areas. Moreover, this antibody may allow more accurate postmortem evaluations of Cdk5 protein expression, and thus serve as a valuable new reagent for neuropathology. Anti-CDK5 antibody is ideal for investigators involved in Cell Signaling, Neuroscience, Signal Transduction research.

Gene Name: CDK5

ID gène: 140908

UniProt: Q03114

Pathways: Cycle Cellulaire, Regulation of Muscle Cell Differentiation, Synaptic Membrane, Regulation of Cell Size, Skeletal Muscle Fiber Development, Synaptic Vesicle Exocytosis