CASK anticorps

N° du produit ABIN6658140

N° du produit (Fournisseur): 200-301-f02

Cet anticorps Souris Monoclonal détecte spécifiquement CASK dans WB, IHC et IP. Il présente une réactivité envers Rat.

Aperçu rapide pour CASK anticorps (ABIN6658140)

Antigène: CASK (Calcium/calmodulin-Dependent serine Protein Kinase (MAGUK Family) (CASK))

Reactivité: Rat

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CASK est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)

Clone: S56A-50

Détail du produit anti-CASK anticorps

N° du produit (Fournisseur): 200-301-f02

Fournisseur: Rockland

Fonction: CASK Antibody

Réactivité croisée (Details): A BLAST analysis was used to suggest cross-reactivity with CASK from Mouse, Rat, Human, Zebrafish, and Xenopus based on 100 % homology with the immunizing sequence.

Purification: Anti-CASK Antibody was purified by Protein G chromatography.

Stérilité: Sterile filtered

Immunogène: CASK Antibody was produced in mice by repeated immunizations with a fusion protein of rat CASK/Lin2.

Isotype: IgG1

Information d'application

Indications d'application:

Immunoprecipitation_Dilution: User Optimized

Immunohistochemistry_Dilution: User Optimized

Western_Blot_Dilution: 1:1000

Commentaires:

Anti-CASK Antibody is tested for use in WB and IHC. Expect a band approximately ~100kDa on specific lysates. Specific conditions for reactivity should be optimized by the end user.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer:

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

Stabilizer: 50 % (v/v) Glycerol

Stock: 4 °C,-20 °C

Stockage commentaire: Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.

Date de péremption: 12 months

Détails sur CASK

Antigène: CASK (Calcium/calmodulin-Dependent serine Protein Kinase (MAGUK Family) (CASK))

Autre désignation: CASK

Sujet:

Synonyms: Peripheral plasma membrane protein CASK, Calcium/calmodulin-dependent serine protein kinase

Background: CASK (calmodulin sensitive kinase) is a ~112 kDa member of the membrane associated quanylate kinase (MAGUK) protein family. It is an adaptor protein with a calcium/calmodulin-dependent protein kinase domain, a SH3 domain, aguanylate kinase homology domain (GUK) and a PDZ domain. CASK links transmembrane proteins to the cytoskeleton and signaling molecules. In particular, CASK binds to Neurexin to stabilize pre- and post-synaptic structrures. While most of CASK proteins are cytoplasmic, a portion of the protein enters the nucleus, where it acts as a transcriptional co-activator. Manifesting the importance of CASK, transgenic mice with insertional mutations die within 24 hours of births. CASK is also localized in the nuclei of basal keratinocytes in newborn rodent skin and developing hair follicles. It may play a role in wound healing.

Gene Name: Cask

ID gène: 29647

NCBI Accession: NP_071520

UniProt: Q62915

Pathways: Synaptic Vesicle Exocytosis