GRIN2B anticorps (pSer1166)

N° du produit ABIN6658155

N° du produit (Fournisseur): 600-401-x17

Cet anticorps Lapin Polyclonal détecte spécifiquement GRIN2B dans WB et ELISA. Il présente une réactivité envers Rat.

Aperçu rapide pour GRIN2B anticorps (pSer1166) (ABIN6658155)

Antigène: GRIN2B (Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2B (GRIN2B))

Reactivité: Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GRIN2B est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-GRIN2B anticorps

Épitope: pSer1166

N° du produit (Fournisseur): 600-401-x17

Fournisseur: Rockland

Fonction: NMDA NR2B Subunit Phospho S1166 Antibody

Réactivité croisée (Details): Anti-Phospho-Ser1166 NMDA Receptor NR2B Subunit Antibody is directed against NMDA protein phosphorylated at S1166.

Purification: The antibody was prepared from monospecific antiserum by immunoaffinity chromatography using phospho peptide coupled to agarose beads followed by solid phase adsorption(s) against non-phospho peptide and non-specific peptide to remove any unwanted reactivities.

Stérilité: Sterile filtered

Immunogène: Anti-Phospho-Ser1166 NMDA Receptor NR2B Subunit Antibody was produced in rabbits by repeated immunizations with a synthetic phospho-peptide corresponding to amino acid residues surrounding Ser1166 of rat NMDA Receptor NR2B Subunit conjugated to KLH.

Isotype: IgG

Information d'application

Indications d'application:

ELISA_Dilution: 1:2,500

Western_Blot_Dilution: 1:250

Commentaires:

Anti-Phospho-Ser1166 NMDA Receptor NR2B Subunit Antibody is tested for Western Blots and is specific for the ~180 kDa NMDAR NR2B subunit phosphorylated at Ser1166. Immunolabeling of the NMDA NR2B subunit band is blocked by the phosphopeptide used as the antigen but not by the corresponding dephosphopeptide. Specific conditions for reactivity should be optimized by the end user.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer:

Buffer: 0.01 M HEPES, 0.15 M Sodium Chloride, pH 7.5

Stabilizer: 0.1 mg/mL Bovine Serum Albumin (BSA) - IgG and Protease free, 50 % (v/v) Glycerol

Preservative: None

Agent conservateur: Without preservative

Stock: -20 °C

Stockage commentaire: Store vial at -20° C prior to opening in undiluted aliquots. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature.

Date de péremption: 12 months

Détails sur GRIN2B

Antigène: GRIN2B (Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2B (GRIN2B))

Autre désignation: NMDA NR2B Subunit

Sujet:

Synonyms: Glutamate receptor ionotropic, NMDA 2B, GluN2B, Glutamate [NMDA] receptor subunit epsilon-2, N-methyl D-aspartate receptor subtype 2B, NMDAR2B, NR2B

Background: The NMDA receptor (NMDAR) plays an essential role in memory, neuronal development and it has also been implicated in several disorders of the central nervous system including Alzheimer's, epilepsy and ischemic neuronal cell death. Overexpression of the NR2B-subunit of the NMDA Receptor has been associated with increases in learning and memory while aged, memory impaired animals have deficiencies in NR2B expression. Phosphorylation of Ser1166 is thought to play an essential role in memory and neuronal development. NMDA pS1166 Receptor NR2B Subunit Antibody is ideal for researchers interested in neuroscience research.

Gene Name: GRIN2B

ID gène: 24410

NCBI Accession: NP_036706

UniProt: Q00960

Pathways: Response to Growth Hormone Stimulus, Synaptic Membrane, Feeding Behaviour, Regulation of long-term Neuronal Synaptic Plasticity