MAPT anticorps (pSer416)

N° du produit ABIN6658211

N° du produit (Fournisseur): 612-401-e42

Cet anticorps anti-MAPT est un anticorps Lapin Polyclonal détectant MAPT dans WB et IHC. Adapté pour Rat.

Aperçu rapide pour MAPT anticorps (pSer416) (ABIN6658211)

Antigène: MAPT (Microtubule-Associated Protein tau (MAPT))

Reactivité: Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MAPT est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-MAPT anticorps

Épitope: pSer416

N° du produit (Fournisseur): 612-401-e42

Fournisseur: Rockland

Fonction: Tau phospho S416 Antibody

Réactivité croisée (Details): Anti-Tau pS416 antibody is directed against rat Tau.

Purification: Tau pS416 antibodies was prepared from monospecific antiserum by immunoaffinity chromatography using phospho peptide coupled to agarose beads followed by solid phase adsorption(s) against non-phospho peptide and non-specific peptide to remove any unwanted reactivities.

Immunogène: Anti-Tau pS416 Antibody was produced in rabbit by repeated immunizations with synthetic phospho-peptide corresponding to amino acid residues surrounding Ser416 of the Tau protein.

Isotype: IgG

Information d'application

Indications d'application: Optional[Neutralization_Dilution]: 1:1000

Commentaires:

Anti-Tau pS416 (Rabbit) antibody is tested for use in Western Blot and IHC. Expect bands approximately 59, 65, 68 kDa in size corresponding to tau proteins phosphorylated at Ser416 in the appropriate cell lysate or extract. Researchers should determine optimal titers for applications that are not stated below.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer:

Buffer: 0.01 M HEPES, 0.15 M Sodium Chloride, pH 7.5

Stabilizer: 0.1 mg/mL Bovine Serum Albumin (BSA) - IgG and Protease free, 50 % (v/v) Glycerol

Stock: 4 °C,-20 °C

Stockage commentaire: Store vial at -20° C prior to opening.  This product is stable at 4° C as an undiluted liquid.  For extended storage, aliquot contents and freeze at -20° C or below.  Avoid cycles of freezing and thawing. Dilute only prior to immediate use.

Date de péremption: 12 months

Détails sur MAPT

Antigène: MAPT (Microtubule-Associated Protein tau (MAPT))

Autre désignation: Mapt

Sujet:

Synonyms: Microtubule-associated protein tau, Neurofibrillary tangle protein, Paired helical filament-tau, PHF-tau

Background: Tau pS416 Antibody detects Tau, which s a key microtubule-associated protein that plays an important role in the formation of microtubules in axons. Six tau isoforms have been identified as products of a single gene produced by alternative mRNA splicing. Tau mutations have been implicated in many neurodegenerative disorders such as Alzheimer's disease (AD), Pick's disease and progressive supranuclear palsy. It has been well documented that hyperphosphorylated tau is a major component of paired helical filaments in AD brain. Serine 416 has been demonstrated to be a major phosphorylation site in vitro by CaM kinase II. Anti-Tau pS416 Antibody is ideal for investigators involved in Cell Signaling, Neuroscience, Signal Transduction research.

Gene Name: MAPT

ID gène: 69329

UniProt: P19332

Pathways: Signalisation MAPK, Dynamique des Microtubules, M Phase, Regulation of Cell Size