GABBR2 anticorps (pSer783)

N° du produit ABIN6658229

N° du produit (Fournisseur): 612-401-d53

Cet anticorps anti-GABBR2 est un anticorps Lapin Polyclonal détectant GABBR2 dans WB, IHC et FM. Adapté pour Rat. Ce Primary Antibody a été cité dans 1 publication.

Aperçu rapide pour GABBR2 anticorps (pSer783) (ABIN6658229)

Antigène: GABBR2 (gamma-aminobutyric Acid (GABA) B Receptor, 2 (GABBR2))

Reactivité: Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GABBR2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Fluorescence Microscopy (FM)

Détail du produit anti-GABBR2 anticorps

Épitope: pSer783

N° du produit (Fournisseur): 612-401-d53

Fournisseur: Rockland

Fonction: GABA(B) Receptor 2 phospho S783 Antibody

Réactivité croisée (Details): Anti-GABA(B) Receptor 2 pS783 Antibody is directed against rat phosphorylated GABA(B) Receptor 2.

Purification: The antibody was affinity purified from monospecific antiserum by immunoaffinity purification.

Immunogène: Anti-GABA(B) Receptor 2 pS783 Antibody was produced by repeated immunizations with synthetic phospho-peptide corresponding to amino acid residues surrounding Ser 783 of rat GABAB R2.

Isotype: IgG

Information d'application

Indications d'application:

IF_Microscopy_Dilution: 1:500

Western_Blot_Dilution: 1:1000

Commentaires:

Anti-GABA(B) Receptor 2 pS783 (Rabbit) antibody is tested for use in Western Blotting, ICC, and IHC. Specific conditions for reactivity should be optimized by the end user. Expect a band of approximately 102 kDa in size corresponding to GABA(B) receptor 2 protein phosphorylated at Ser783 in the appropriate cell lysate or extract.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer:

Buffer: 0.01 M HEPES, 0.15 M Sodium Chloride, pH 7.5

Stabilizer: 0.1 mg/mL Bovine Serum Albumin (BSA) - IgG and Protease free, 50 % (v/v) Glycerol

Stock: 4 °C,-20 °C

Stockage commentaire: Store vial at -20° C prior to opening.  This product is stable at 4° C as an undiluted liquid.  For extended storage, aliquot contents and freeze at -20° C or below.  Avoid cycles of freezing and thawing. Dilute only prior to immediate use.

Date de péremption: 12 months

Références pour anticorps anti-GABBR2 (ABIN6658229)

Wu, Kuo, Min, Chen, Yang: "Extracellular Signal-Regulated Kinases Mediate an Autoregulation of GABAB-Receptor-Activated Whole-Cell Current in Locus Coeruleus Neurons." dans: Scientific reports, Vol. 10, Issue 1, pp. 7869, (2020) (PubMed).

Détails sur GABBR2

Antigène: GABBR2 (gamma-aminobutyric Acid (GABA) B Receptor, 2 (GABBR2))

Autre désignation: GABA(B) Receptor 2

Sujet:

Synonyms: Gamma-aminobutyric acid type B receptor subunit 2, GABA-B-R2, GABA-BR2, GABABR2, Gb2, G-protein coupled receptor 51

Background: Anti-GABA(A) Receptor 2 pS783 Antibody detects phosphorylated GABA(A) Receptor 2. Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system. There are two major classes of GABA receptors: the GABAA and the GABAB subtype of receptors. GABAB receptors are heterodimeric G protein-coupled receptors that mediate slow synaptic inhibition in the central nervous system. It has recently been demonstrated that AMPK binds directly to GABAB receptors and phosphorylates S783 in the cytoplasmic tail of the R2 subunit and that S783 plays a critical role in enhancing neuronal survival after ischemia as phosphorylation of S783 is evident in many brain regions and is increased dramatically after ischemic injury to the brain. GABA(B) Receptor 2 pS783 antibody is ideal for investigators involved in Neuroscience.

Gene Name: GABBR2

ID gène: 83633, 8393403

UniProt: O88871

Pathways: cAMP Metabolic Process