GABRG2 anticorps

N° du produit ABIN6658275

Détail du produit anti-GABRG2 anticorps

Antigène: GABRG2 (gamma-aminobutyric Acid (GABA) A Receptor, gamma 2 (GABRG2))

Reactivité: Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GABRG2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Purification: Anti-GABA(A) Receptor gamma 2 Antibody is directed against rat GABA(A) Receptor gamma 2. The antibody was prepared from monospecific neat serum. Expect reactivity with the following species based on 100% sequence homology: chicken, human, mouse, non-human primate, zebra fish.

Immunogène:

Immunogen: Anti-GABA(A) Receptor gamma 2 Antibody was produced by repeated immunizations with GABA(A) Receptor gamma 2- Synthetic peptide corresponding to amino acid residues specific to the gamma 2 subunit.

Immunogen Type: Peptide

Information d'application

Indications d'application:

Immunohistochemistry Dilution: 1:400

Application Note: Anti-GABA(A) Receptor gamma 2 (Rabbit) antibody is suitable for use in Western Blotting and IHC. Expect a band of approximately 46 kDa in size corresponding γ2-subunit of the GABAA receptor in Western blots of rat brain extracts. Specific conditions should by optimized by the end user.

Western Blot Dilution: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Stock: 4 °C,-20 °C

Stockage commentaire: Store vial at -20° C prior to opening.  This product is stable at 4° C as an undiluted liquid.  For extended storage, aliquot contents and freeze at -20° C or below.  Avoid cycles of freezing and thawing. Dilute only prior to immediate use.

Détails sur GABRG2

Antigène: GABRG2 (gamma-aminobutyric Acid (GABA) A Receptor, gamma 2 (GABRG2))

Autre désignation: GABA(A) Receptor gamma 2 (GABRG2 Produits)

Synonymes: anticorps cae2, anticorps eca2, anticorps gabrg1, anticorps gefsp3, anticorps si:ch211-145n14.1, anticorps CAE2, anticorps ECA2, anticorps GEFSP3, anticorps GABAA-R, anticorps Gabrg-2, anticorps gamma2, anticorps gamma-aminobutyric acid type A receptor gamma2 subunit, anticorps gamma-aminobutyric acid (GABA) A receptor, gamma 2, anticorps gamma-aminobutyric acid type A receptor gamma 2 subunit, anticorps gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2, anticorps GABRG2, anticorps gabrg2, anticorps Gabrg2

Sujet:

Synonyms: rabbit anti-GABA(A) Receptor gamma 2 Antibody, Gamma-aminobutyric acid receptor subunit gamma-2, GABA(A) receptor subunit gamma-2, Gabrg2

Background: Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl- channel associated with the GABAA receptor (GABAA-R) sub-type. GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and substance abuse. The GABAA-R is a multimeric subunit complex. To date six αs, four βs and four γs, plus alternative splicing variants of some of these subunits, have been identified. Injection in oocytes or mammalian cell lines of cRNA coding for α- and β-subunits results in the expression of functional GABAA-Rs sensitive to GABA. However, co-expression of a γ-subunit is required for benzodiazepine modulation. The various effects of the benzodiazepines in brain may also be mediated via different α-subunits of the receptor. Phosphorylation of β-subunits of the receptor has been shown to modulate GABAA-R function. Anti-GABA(A) Receptor gamma 2 antibody is ideal for investigators involved in Neuroscience.

Gene Name: GABRG2

ID gène: 29709

UniProt: P18508