GABRG2 anticorps (Cytoplasmic Loop)

N° du produit ABIN6658227

Détail du produit anti-GABRG2 anticorps

Antigène: GABRG2 (gamma-aminobutyric Acid (GABA) A Receptor, gamma 2 (GABRG2))

Épitope: Cytoplasmic Loop

Reactivité: Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GABRG2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Réactivité croisée: Souris, Rat (Rattus)

Purification: Anti-GABA(A) Receptor gamma 2 Antibody is directed against rat GABA(A) Receptor gamma 2. The antibody was affinity purified from monospecific antiserum by immune affinity purification. Reactivity is expected from the following species based on 100% sequence homology: bovine, chicken, canine, human, mouse, and non-human primate.

Immunogène:

Immunogen: Anti-GABA(A) Receptor gamma 2 Antibody was produced by repeated immunizations with recombinant fusion proteins from the cytoplasmic loop of the gamma 2 subunit.

Immunogen Type: Recombinant Protein

Isotype: IgG

Information d'application

Indications d'application:

Immunohistochemistry Dilution: 1:100

Application Note: Anti-GABA(A) Receptor gamma 2 (Rabbit) antibody is suitable for use in Western Blotting and IHC. Specific conditions for reactivity should be optimized by the end user. Expect a band of 46 kDa in size corresponding to the gamma 2 subunit of the GABA(A) receptor in the appropriate cell lysate or extract.

Western Blot Dilution: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer:

Buffer: 0.01 M HEPES, 0.15 M Sodium Chloride, pH 7.5

Stabilizer: 0.1 mg/mL Bovine Serum Albumin (BSA) - IgG and Protease free, 50 % (v/v) Glycerol

Stock: 4 °C,-20 °C

Stockage commentaire: Store vial at -20° C prior to opening. This product is stable at 4° C as an undiluted liquid. For extended storage, aliquot contents and freeze at -20° C or below. Avoid cycles of freezing and thawing. Dilute only prior to immediate use.

Détails sur GABRG2

Antigène: GABRG2 (gamma-aminobutyric Acid (GABA) A Receptor, gamma 2 (GABRG2))

Autre désignation: GABA(A) Receptor gamma 2 (GABRG2 Produits)

Synonymes: anticorps cae2, anticorps eca2, anticorps gabrg1, anticorps gefsp3, anticorps si:ch211-145n14.1, anticorps CAE2, anticorps ECA2, anticorps GEFSP3, anticorps GABAA-R, anticorps Gabrg-2, anticorps gamma2, anticorps gamma-aminobutyric acid type A receptor gamma2 subunit, anticorps gamma-aminobutyric acid (GABA) A receptor, gamma 2, anticorps gamma-aminobutyric acid type A receptor gamma 2 subunit, anticorps gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2, anticorps GABRG2, anticorps gabrg2, anticorps Gabrg2

Sujet:

Synonyms: Gamma-aminobutyric acid receptor subunit gamma-2, GABA(A) receptor subunit gamma-2, Gabrg2

Background: Anti-GABA(A) Receptor gamma 2 Antibody detects GABA(A) Receptor gamma 2. Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl- channel associated with the GABAA receptor (GABAA-R) subtype. GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and substance abuse. The GABAA-R is a multimeric subunit complex. To date six alphas, four betas and four gammas, plus alternative splicing variants of some of these subunits, have been identified. Injection in oocytes or mammalian cell lines of cRNA coding for alpha- and beta-subunits results in the expression of functional GABAA-Rs sensitive to GABA. However, coexpression of a gamma-subunit is required for benzodiazepine modulation. The various effects of the benzodiazepines in brain may also be mediated via different alpha-subunits of the receptor. Anti-GABA(A) Receptor gamma 2 Antibody is ideal for investigators involved in Neuroscience.

Gene Name: GABRG2

ID gène: 29709

NCBI Accession: NP_899156

UniProt: P18508