tau anticorps (Atto 390)

N° du produit ABIN6698754

Cet anticorps anti-tau est un anticorps Lapin Polyclonal détectant tau dans WB et ELISA. Adapté pour Humain et Souris.

Aperçu rapide pour tau anticorps (Atto 390) (ABIN6698754)

Antigène: tau (tau Protein)

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp tau est conjugé à/à la Atto 390

Application: Western Blotting (WB), ELISA

Détail du produit anti-tau anticorps (Atto 390)

Specificité: Detects ~45.8kda.

Purification: Protein A Purified

Immunogène: Synthetic peptide from the full length of Human Tau

Information d'application

Indications d'application:

• WB (1:1000)
• optimal dilutions for assays should be determined by the user.
• optimal dilutions for assays should be determined by the user.

Commentaires:

A 1:1000 dilution of ABIN6698754 was sufficient for detection of Tau in 10 μg of human SH-SY5Y cell lysate cell lysates by ECL immunoblot analysis using goat anti-rabbit IgG:HRP as the secondary antibody.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS pH 7.4, 50 % glycerol, 0.09 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Détails sur tau

Antigène: tau (tau Protein)

Autre désignation: Tau

Sujet: Alzheimer's Disease (AD) is the most common neurodegenerative disease, affecting 10 % of seniors over the age of 65 (1). It was named after Alois Alzheimer, a German scientist who discovered tangled bundles of fibrils where neurons had once been in the brain of a deceased patient in 1907 (2). Tau (tubulin-associated unit) is normally located in the axons of neurons where it stabilizes microtubules. Tauopathies such as AD are characterized by neurofibrillary tangles containing hyperphosphorylated tau fibrils (3). There are six isoforms of tau in the adult human brain: three with four repeat units (4R) and three with three repeat units (3R) (4). K18 is a truncated form of human tau containing only the 4 microtubule binding repeats (5). P301L (PL) is a mutation where proline is replaced by leucine at codon 301 of tau, and has been linked to frontotemporal dementia (6).

ID gène: 4137

UniProt: P10636