CCR7 anticorps (Alexa Fluor 488)

N° du produit ABIN6721846

Cet anticorps Souris Monoclonal détecte spécifiquement CCR7 dans FACS. Il présente une réactivité envers Humain.

Aperçu rapide pour CCR7 anticorps (Alexa Fluor 488) (ABIN6721846)

Antigène: CCR7 (Chemokine (C-C Motif) Receptor 7 (CCR7))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CCR7 est conjugé à/à la Alexa Fluor 488

Application: Flow Cytometry (FACS)

Clone: G043H7

Détail du produit anti-CCR7 anticorps (Alexa Fluor 488)

Isotype: IgG2a kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Buffer: PBS with 0.05 % Proclin300, 1 % BSA

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store at 2~8°C and protected from prolonged exposure to light. Do not freeze.

Détails sur CCR7

Antigène: CCR7 (Chemokine (C-C Motif) Receptor 7 (CCR7))

Autre désignation: CD197/CCR7

Sujet:

Synonyms: CMKBR7, EBI1, EVI1,CCR-7,CDw197

Background: CCR7, also known as CD197, is a chemokine receptor that binds CCL19 and CCL21. CCR7 and its ligands link innate and adaptive immunity by affecting interactions between T cells and dendritic cells and their downstream effect. Naive T cells enter the lymph node through high endothelial venules, which express CCL21. Dendritic cells and macrophages enter the lymph node through afferent lymphatics. The encounter of T cells and dendritic cells in the T cell zone is CCR7-dependent. In addition, during immunological surveillance, B cells recirculate between B-cell-rich compartments (follicles or B cell zones) in secondary lymphoid organs, surveying for antigen. After antigen binding, B cells move to the boundary of B and T zones to interact with T-helper cells, this B cell migration is directed by CCR7 and its ligands. CCR7-positive cancer cell expression has been associated with lymph node metastasis. Product Details

ID gène: 1236

UniProt: P32248

Pathways: Regulation of Actin Filament Polymerization, Positive Regulation of Immune Effector Process