KCNMA1 anticorps (AA 1131-1236)

N° du produit ABIN672426

Détail du produit anti-KCNMA1 anticorps

Antigène: KCNMA1 (Potassium Large Conductance Calcium-Activated Channel, Subfamily M, alpha Member 1 (KCNMA1))

Épitope: AA 1131-1236

Reactivité: Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp KCNMA1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Réactivité croisée: Souris, Rat

Homologie: Human,Dog,Cow,Sheep,Pig,Rabbit

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human BK channel

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Références pour anticorps anti-KCNMA1 (ABIN672426)

Sudduth, Weekman, Price, Gooch, Woolums, Norris, Wilcock: "Time-course of glial changes in the hyperhomocysteinemia model of vascular cognitive impairment and dementia (VCID)." dans: Neuroscience, Vol. 341, pp. 42-51, (2016) (PubMed).

Détails sur KCNMA1

Antigène: KCNMA1 (Potassium Large Conductance Calcium-Activated Channel, Subfamily M, alpha Member 1 (KCNMA1))

Autre désignation: BK channel (KCNMA1 Produits)

Synonymes: anticorps BKTM, anticorps KCa1.1, anticorps MaxiK, anticorps SAKCA, anticorps SLO, anticorps SLO-ALPHA, anticorps SLO1, anticorps bA205K10.1, anticorps mSLO1, anticorps DDBDRAFT_0190653, anticorps DDBDRAFT_0235401, anticorps DDB_0190653, anticorps DDB_0235401, anticorps KCNMA, anticorps KCNMA1, anticorps 5730414M22Rik, anticorps BKCa, anticorps Slo, anticorps Slo1, anticorps mSlo, anticorps mSlo1, anticorps KCNMA1b, anticorps KCNMA1c, anticorps Kcnma, anticorps bktm, anticorps kcnma1-A, anticorps sakca, anticorps cSlo, anticorps slo1, anticorps kcnma1, anticorps si:ch211-39f22.2, anticorps BcDNA:GH10751, anticorps CG10693, anticorps Dmel\CG10693, anticorps Dslo, anticorps dSlo, anticorps dSlo1, anticorps dslo, anticorps fSlo, anticorps potassium calcium-activated channel subfamily M alpha 1, anticorps calcium-activated BK potassium channel, alpha subunit, anticorps potassium large conductance calcium-activated channel, subfamily M, alpha member 1, anticorps potassium calcium-activated channel subfamily M alpha 1 L homeolog, anticorps potassium large conductance calcium-activated channel, subfamily M, alpha member 1a, anticorps calcium-activated potassium channel subunit alpha-1, anticorps slowpoke, anticorps KCNMA1, anticorps kcnma1, anticorps Kcnma1, anticorps kcnma1.L, anticorps kcnma1a, anticorps LOC100454095, anticorps slo

Sujet:

Synonyms: SLO, BKTM, SLO1, MaxiK, SAKCA, mSLO1, KCa1.1, SLO-ALPHA, bA205K10.1, Calcium-activated potassium channel subunit alpha-1, BK channel, BKCA alpha, Calcium-activated potassium channel, subfamily M subunit alpha-1, K(VCA)alpha, Maxi K channel, Slowpoke homolog, Slo homolog, hSlo, KCNMA1, KCNMA

Background: Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+). It is also activated by the concentration of cytosolic Mg(2+). Its activation dampens the excitatory events that elevate the cytosolic Ca(2+) concentration and/or depolarize the cell membrane. It therefore contributes to repolarization of the membrane potential. Plays a key role in controlling excitability in a number of systems, such as regulation of the contraction of smooth muscle, the tuning of hair cells in the cochlea, regulation of transmitter release, and innate immunity. In smooth muscles, its activation by high level of Ca(2+), caused by ryanodine receptors in the sarcoplasmic reticulum, regulates the membrane potential. In cochlea cells, its number and kinetic properties partly determine the characteristic frequency of each hair cell and thereby helps to establish a tonotopic map. Kinetics of KCNMA1 channels are determined by alternative splicing, phosphorylation status and its combination with modulating beta subunits. Highly sensitive to both iberiotoxin (IbTx) and charybdotoxin (CTX).

ID gène: 3778

UniProt: Q12791

Pathways: Regulation of Hormone Metabolic Process, Sensory Perception of Sound