CCL5 anticorps (AA 62-91)

N° du produit ABIN674949

Détail du produit anti-CCL5 anticorps

Antigène: CCL5 (Chemokine (C-C Motif) Ligand 5 (CCL5))

Épitope: AA 62-91

Reactivité: Humain, Souris, Cobaye, Porc

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CCL5 est non-conjugé

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Réactivité croisée: Cobaye, Humain, Souris, Porc

Homologie: Rat,Dog,Cow,Sheep,Rabbit

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human CCL5

Isotype: IgG

Information d'application

Indications d'application: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Références pour anticorps anti-CCL5 (ABIN674949)

Irie, Tomofuji, Ekuni, Fukuhara, Uchida, Kataoka, Kobayashi, Kikuchi, Mitani, Shimazaki, Morita: "Age-related changes of CD4+T cell migration and cytokine expression in germ-free and SPF mice periodontium." dans: Archives of oral biology, Vol. 87, pp. 72-78, (2018) (PubMed).

Sun, Roberts, Mauerhan, Hanley: "Biological effects and osteoarthritic disease-modifying activity of small molecule CM-01." dans: Journal of orthopaedic research : official publication of the Orthopaedic Research Society, (2017) (PubMed).

Sun, Haines, Roberts, Ruffolo, Mauerhan, Mihalko, Ingram, Cox, Hanley: "Disease-modifying effects of phosphocitrate and phosphocitrate-β-ethyl ester on partial meniscectomy-induced osteoarthritis." dans: BMC musculoskeletal disorders, Vol. 16, pp. 270, (2016) (PubMed).

Hwaiz, Rahman, Syk, Zhang, Thorlacius: "Rac1-dependent secretion of platelet-derived CCL5 regulates neutrophil recruitment via activation of alveolar macrophages in septic lung injury." dans: Journal of leukocyte biology, (2015) (PubMed).

Herder, Iskandar, Kegler, Hansmann, Elmarabet, Khan, Kalkuhl, Deschl, Baumgärtner, Ulrich, Beineke: "Dynamic Changes of Microglia/Macrophage M1 and M2 Polarization in Theiler's Murine Encephalomyelitis." dans: Brain pathology (Zurich, Switzerland), Vol. 25, Issue 6, pp. 712-23, (2015) (PubMed).

Pattappa, Peroglio, Sakai, Mochida, Benneker, Alini, Grad: "CCL5/RANTES is a key chemoattractant released by degenerative intervertebral discs in organ culture." dans: European cells & materials, Vol. 27, pp. 124-36; discussion 136, (2014) (PubMed).

Détails sur CCL5

Antigène: CCL5 (Chemokine (C-C Motif) Ligand 5 (CCL5))

Autre désignation: CCL5/RANTES (CCL5 Produits)

Synonymes: anticorps Rantes, anticorps Scya5, anticorps D17S136E, anticorps RANTES, anticorps SCYA5, anticorps SIS-delta, anticorps SISd, anticorps TCP228, anticorps eoCP, anticorps MuRantes, anticorps C-C motif chemokine 5-like, anticorps C-C motif chemokine ligand 5, anticorps chemokine (C-C motif) ligand 5, anticorps LOC100230935, anticorps CCL5, anticorps Ccl5

Sujet:

Synonyms: SISd, eoCP, SCYA5, RANTES, TCP228, D17S136E, SIS-delta, C-C motif chemokine 5, Eosinophil chemotactic cytokine, Small-inducible cytokine A5, T cell-specific protein P228, T-cell-specific protein RANTES, CCL5

Background: Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant RANTES protein induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form RANTES(3-68) acts as a natural chemotaxis inhibitor and is a more potent inhibitor of HIV-1-infection. The second processed form RANTES(4-68) exhibits reduced chemotactic and HIV-suppressive activity compared with RANTES(1-68) and RANTES(3-68) and is generated by an unidentified enzyme associated with monocytes and neutrophils (PubMed:1679162, PubMed:13864, PubMed:8525373, PubMed:9516414, PubMed:15923218). May also be an agonist of the G protein-coupled receptor GPR75, stimulating inositol trisphosphate production and calcium mobilization through its activation. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells (PubMed:23979485).

ID gène: 6352

UniProt: P13501

Pathways: Cellular Response to Molecule of Bacterial Origin, Regulation of G-Protein Coupled Receptor Protein Signaling, Smooth Muscle Cell Migration