CYLD anticorps (N-Term)

N° du produit ABIN6756791

Cet anticorps anti-CYLD est un anticorps Lapin Polyclonal détectant CYLD dans WB. Adapté pour Humain et Souris.

Aperçu rapide pour CYLD anticorps (N-Term) (ABIN6756791)

Antigène: CYLD (Cylindromatosis (Turban Tumor Syndrome) (CYLD))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CYLD est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-CYLD anticorps

Épitope: N-Term

Specificité: Human CYLD

Purification: Protein A purified

Immunogène: A recombinant protein fragment from the N-terminal region of human CYLD.

Type of Immunogen: Recombinant protein

Isotype: IgG

Information d'application

Indications d'application: Approved: WB (2 - 5 μg/mL)

Usage: CYLD is involved in multiple physiological processes including immune response, osteoclastogenesis and spermatogenesis. It is a tumor suppressor via its negative regulation of NF-kB activation. CYLD is a deubiquitinase, removing ubiquitin chains from tumor-necrosis factor receptor-associated factor 2 (TRAF2) and thereby preventing its activation of IkB, a regulator of NF-kB. NF-kB remains sequestered in the cytoplasm, unable to translocate to the nucleus and initiate cell survival and oncogenetic signaling.

Commentaires:

Target Species of Antibody: Human

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: PBS,  pH 7.4, 0.1 mg/mL BSA, 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: avoid freeze thaw cycles

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze-thaw cycles.

Détails sur CYLD

Antigène: CYLD (Cylindromatosis (Turban Tumor Syndrome) (CYLD))

Autre désignation: CYLD

Sujet: Name/Gene ID: CYLD

Synonyms: CYLD, CDMT, Deubiquitinating enzyme CYLD, CYLDI, EAC, HSPC057, MFT1, MFT, SBS, TEM, BRSS, Ubiquitin thiolesterase CYLD, USPL2, CYLD1, KIAA0849, Ubiquitin thioesterase CYLD

ID gène: 1540

Pathways: Apoptose, Activation of Innate immune Response