LAMP1 anticorps (AA 301-417)

N° du produit ABIN676088

Détail du produit anti-LAMP1 anticorps

Antigène: LAMP1 (Lysosomal-Associated Membrane Protein 1 (LAMP1))

Épitope: AA 301-417

Reactivité: Humain, Souris, Rat, Singe

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp LAMP1 est non-conjugé

Application: Western Blotting (WB), Flow Cytometry (FACS), ELISA, Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Réactivité croisée: Humain, Singe, Souris, Rat

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human LAMP-1

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Références pour anticorps anti-LAMP1 (ABIN676088)

Bechor, Nachmias, Elia, Haim, Vatarescu, Leikin-Frenkel, Gericke, Tarnovscki, Las, Rudich: "Adipose tissue conditioned media support macrophage lipid-droplet biogenesis by interfering with autophagic flux." dans: Biochimica et biophysica acta, Vol. 1862, Issue 9, pp. 1001-1012, (2017) (PubMed).

Pan, Kang, Wang, Liu, Oshima, Huang, Zhang, Yearsley, Yu, Wang: "Black Raspberries Enhance Natural Killer Cell Infiltration into the Colon and Suppress the Progression of Colorectal Cancer." dans: Frontiers in immunology, Vol. 8, pp. 997, (2017) (PubMed).

Guo, Zhao, Qiu, Deis, Huang, Tang, Chen: "Niemann-Pick type C2 deficiency impairs autophagy-lysosomal activity, mitochondrial function, and TLR signaling in adipocytes." dans: Journal of lipid research, Vol. 57, Issue 9, pp. 1644-58, (2016) (PubMed).

Jeong, Lee, Yang, Seong: "Combination of macrophage inflammatory protein 1 alpha with existing therapies to enhance the antitumor effects on murine hepatoma." dans: Journal of radiation research, (2014) (PubMed).

Sun, Huang, Wang, Yu, Li, Li, Hu, Hao, Ishag, Mao: "Porcine reproductive and respiratory syndrome virus induces autophagy to promote virus replication." dans: Autophagy, Vol. 8, Issue 10, pp. 1434-47, (2012) (PubMed).

Détails sur LAMP1

Antigène: LAMP1 (Lysosomal-Associated Membrane Protein 1 (LAMP1))

Autre désignation: LAMP-1 (LAMP1 Produits)

Synonymes: anticorps CD107a, anticorps LAMPA, anticorps LGP120, anticorps AI196048, anticorps Lamp-1, anticorps LEP100, anticorps LAMP-1, anticorps LGP-A, anticorps Lgpa, anticorps Lysosome-associated membrane protein 1, anticorps cd107a, anticorps lamp-1, anticorps lamp1, anticorps lampa, anticorps lgp120, anticorps rexp76, anticorps lysosomal associated membrane protein 1, anticorps lysosomal-associated membrane protein 1, anticorps lysosomal-associated membrane protein 1 L homeolog, anticorps LAMP1, anticorps Lamp1, anticorps lamp1.L

Sujet:

Synonyms: LAMPA, CD17a, LGP12, Lysosome-associated membrane glycoprotein 1, LAMP-1, Lysosome-associated membrane protein 1, CD17 antigen-like family member A, LAMP1

Background: Lysosome associated membrane protein (LAMP1), also known as lgp120 or lgpA, is a type 1 integral membrane protein that is transported from trans Golgi networks to endosomes and then lysosomes. Upon cell activation, LAMP1 transfer to the plasma membrane is dependent on a carboxyl terminal tyrosine based motif (YXXI). Perturbation in the spacing between the tyrosine based motif relative to the membrane abolishes lysosome localization of LAMP1. This mutant protein then cycles between the plasma membrane and the endosome. Cell surface LAMP1 and LAMP2 have been shown to promote adhesion of human peripheral blood mononuclear cells (PBMC) to vascular endothelium, therefore they are possibly involved in the adhesion of PBMCs to the site of inflammation.

ID gène: 3916

UniProt: P11279

Pathways: Autophagy