SMO anticorps (AA 551-650)

N° du produit ABIN680908

Cet anticorps Lapin Polyclonal détecte spécifiquement SMO dans WB, ELISA, IHC (p) et IF (p). Il présente une réactivité envers Humain, Souris et Rat et a été mentionné dans 3+ publications.

Aperçu rapide pour SMO anticorps (AA 551-650) (ABIN680908)

Antigène: SMO (Smoothened Homolog (Drosophila) (SMO))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SMO est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Détail du produit anti-SMO anticorps

Épitope: AA 551-650

Réactivité croisée: Humain, Souris, Rat

Homologie: Dog,Cow,Pig,Horse,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human Smoothened

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IF(IHC-P) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Références pour anticorps anti-SMO (ABIN680908)

Zhou, Zhou, Liu, Shen: "GDC-0449 improves the antitumor activity of nano-doxorubicin in pancreatic cancer in a fibroblast-enriched microenvironment." dans: Scientific reports, Vol. 7, Issue 1, pp. 13379, (2019) (PubMed).

Wang, Zhang, Bai, Wang, Du: "Baicalin Attenuates Alcoholic Liver Injury through Modulation of Hepatic Oxidative Stress, Inflammation and Sonic Hedgehog Pathway in Rats." dans: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, Vol. 39, Issue 3, pp. 1129-40, (2016) (PubMed).

Détails sur SMO

Antigène: SMO (Smoothened Homolog (Drosophila) (SMO))

Autre désignation: Smoothened homolog

Sujet:

Synonyms: Gx, SMOH, FZD11, Smoothened homolog, SMO, Protein Gx

Background: G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO). Required for the accumulation of KIF7 and GLI3 in the cilia.

ID gène: 6608

UniProt: Q99835

Pathways: Signalisation Hedgehog