HES1 anticorps (AA 41-150)

N° du produit ABIN682393

Cet anticorps Lapin Polyclonal détecte spécifiquement HES1 dans WB, ELISA, FACS, IF (cc), IF (p), IHC (p) et IHC (fro). Il présente une réactivité envers Humain, Souris et Rat et a été mentionné dans 3+ publications.

Aperçu rapide pour HES1 anticorps (AA 41-150) (ABIN682393)

Antigène: HES1 (Hes Family bHLH Transcription Factor 1 (HES1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HES1 est non-conjugé

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Détail du produit anti-HES1 anticorps

Épitope: AA 41-150

Réactivité croisée: Humain, Souris, Rat

Homologie: Cow,Pig,Horse,Rabbit

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human HES1

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Références pour anticorps anti-HES1 (ABIN682393)

Shi, Shu, Yang, Xu, Xing, Liu, Chen, Qi, Liu, Wang, Tang, Xie: "Wnt and Notch signaling pathway involved in wound healing by targeting c-Myc and Hes1 separately." dans: Stem cell research & therapy, Vol. 6, pp. 120, (2015) (PubMed).

Gao, Zhang, Wang, Liu, Zheng, Yang, Huang, Ye, Luo, Xiao: "Hes1 is involved in the self-renewal and tumourigenicity of stem-like cancer cells in colon cancer." dans: Scientific reports, Vol. 4, pp. 3963, (2014) (PubMed).

Long, Qiu, Liu, Fei, Feng, Wang, Zhong, Yi, Liu, Zhang, Han: "Functional recovery and neuronal regeneration of a rat model of epilepsy by transplantation of Hes1-down regulated bone marrow stromal cells." dans: Neuroscience, Vol. 212, pp. 214-24, (2012) (PubMed).

Détails sur HES1

Antigène: HES1 (Hes Family bHLH Transcription Factor 1 (HES1))

Autre désignation: HES1

Sujet:

Synonyms: HHL, HRY, HES-1, bHLHb39, Transcription factor HES-1, Class B basic helix-loop-helix protein 39, Hairy and enhancer of split 1, Hairy homolog, Hairy-like protein, HES1, HL

Background: Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1. Binds DNA on N-box motifs: 5'-CACNAG-3' with high affinity and on E-box motifs: 5'-CANNTG-3' with low affinity (By similarity). May play a role in a functional FA core complex response to DNA cross-link damage, being required for the stability and nuclear localization of FA core complex proteins, as well as for FANCD2 monoubiquitination in response to DNA damage.

ID gène: 3280

UniProt: Q14469

Pathways: Réparation de l'ADN