MFN2 anticorps (AA 1-120)

N° du produit ABIN682528

Cet anticorps Lapin Polyclonal détecte spécifiquement MFN2 dans WB, ELISA, FACS, IHC (p), IF (cc), IF (p) et IHC (fro). Il présente une réactivité envers Humain, Rat, Souris et Lapin et a été mentionné dans 2+ publications.

Aperçu rapide pour MFN2 anticorps (AA 1-120) (ABIN682528)

Antigène: MFN2 (Mitofusin 2 (MFN2))

Reactivité: Humain, Rat, Souris, Lapin

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MFN2 est non-conjugé

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Détail du produit anti-MFN2 anticorps

Épitope: AA 1-120

Réactivité croisée: Humain, Souris, Lapin, Rat

Homologie: Dog,Cow,Pig,Horse,Chicken

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human Mitofusin 2

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Références pour anticorps anti-MFN2 (ABIN682528)

Hui, Lu, Han, Zhou, Liu, Li, Jin: "Resveratrol improves mitochondrial function in the remnant kidney from 5/6 nephrectomized rats." dans: Acta histochemica, Vol. 119, Issue 4, pp. 392-399, (2017) (PubMed).

Ku, Ji, Zhang, Li, Sang: "PM2.5, SO2 and NO2 co-exposure impairs neurobehavior and induces mitochondrial injuries in the mouse brain." dans: Chemosphere, Vol. 163, pp. 27-34, (2016) (PubMed).

Détails sur MFN2

Antigène: MFN2 (Mitofusin 2 (MFN2))

Autre désignation: Mitofusin 2

Sujet:

Synonyms: HSG, MARF, CMT2A, CPRP1, CMT2A2, Mitofusin-2, Transmembrane GTPase MFN2, MFN2, KIAA0214

Background: Essential transmembrane GTPase, which mediates mitochondrial fusion. Fusion of mitochondria occurs in many cell types and constitutes an important step in mitochondria morphology, which is balanced between fusion and fission. MFN2 acts independently of the cytoskeleton. It therefore plays a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes. Overexpression induces the formation of mitochondrial networks. Plays an important role in the regulation of vascular smooth muscle cell proliferation. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy). Is required for PARK2 recruitment to dysfunctional mitochondria. Involved in the control of unfolded protein response (UPR) upon ER stress including activation of apoptosis and autophagy during ER stress. Acts as an upstream regulator of EIF2AK3 and suppresses EIF2AK3 activation under basal conditions.

ID gène: 9927

UniProt: O95140

Pathways: Skeletal Muscle Fiber Development