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IRF7 anticorps (AA 401-503)

IRF7 Reactivité: Humain, Souris, Rat, Porc WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN682603
  • Antigène Voir toutes IRF7 Anticorps
    IRF7 (Interferon Regulatory Factor 7 (IRF7))
    Épitope
    • 17
    • 17
    • 14
    • 11
    • 5
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 401-503
    Reactivité
    • 77
    • 54
    • 53
    • 16
    • 8
    • 3
    • 2
    • 2
    • 1
    Humain, Souris, Rat, Porc
    Hôte
    • 68
    • 10
    Lapin
    Clonalité
    • 57
    • 21
    Polyclonal
    Conjugué
    • 24
    • 6
    • 6
    • 5
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    Cet anticorp IRF7 est non-conjugé
    Application
    • 49
    • 18
    • 17
    • 13
    • 13
    • 12
    • 5
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
     Réactivité croisée
    Humain, Souris, Porc, Rat
    Homologie
    Dog,Cow,Rabbit
    Purification
    Purified by Protein A.
    Immunogène
    KLH conjugated synthetic peptide derived from human IRF7
    Isotype
    IgG
    Top Product
    Discover our top product IRF7 Anticorps primaire
  • Indications d'application
    WB 1:300-5000
    ELISA 1:500-1000
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Date de péremption
    12 months
  • Lopušná, Benkóczka, Lupták, Matúšková, Lukáčiková, Ovečková, Režuchová: "Murine gammaherpesvirus targets type I IFN receptor but not type III IFN receptor early in infection." dans: Cytokine, Vol. 83, pp. 158-70, (2016) (PubMed).

    Cai, Jiang, Pan, Chen, Zhang, Zhu, Cai, Ling, Chen, Xu, Chen: "Transcriptomic analysis of hepatic responses to testosterone deficiency in miniature pigs fed a high-cholesterol diet." dans: BMC genomics, Vol. 16, pp. 59, (2015) (PubMed).

    Han, Choi, Uyangaa, Kim, Kim, Kim, Kim, Eo: "Distinct dictation of Japanese encephalitis virus-induced neuroinflammation and lethality via triggering TLR3 and TLR4 signal pathways." dans: PLoS pathogens, Vol. 10, Issue 9, pp. e1004319, (2014) (PubMed).

  • Antigène
    IRF7 (Interferon Regulatory Factor 7 (IRF7))
    Autre désignation
    IRF7 (IRF7 Produits)
    Synonymes
    anticorps wu:fl24c03, anticorps zgc:66043, anticorps zgc:77947, anticorps IRF7, anticorps irf7, anticorps IRF-7H, anticorps IRF7A, anticorps IRF7B, anticorps IRF7C, anticorps IRF7H, anticorps interferon regulatory factor 7, anticorps irf7, anticorps IRF7, anticorps Irf7
    Sujet

    Synonyms: IRF7A, IRF7B, IRF7C, IRF7H, IRF-7H, Interferon regulatory factor 7, IRF-7, IRF7

    Background: Key transcriptional regulator of type I interferon (IFN)-dependent immune responses and plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Can efficiently activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes and mediate their induction via both the virus-activated, MyD88-independent pathway and the TLR-activated, MyD88-dependent pathway. Required during both the early and late phases of the IFN gene induction but is more critical for the late than for the early phase. Exists in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, becomes phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization where along with other coactivators it can activate transcription of the type I IFN and ISG genes. Can also play a role in regulating adaptive immune responses by inducing PSMB9/LMP2 expression, either directly or through induction of IRF1. Binds to the Q promoter (Qp) of EBV nuclear antigen 1 a (EBNA1) and may play a role in the regulation of EBV latency. Can activate distinct gene expression programs in macrophages and regulate the anti-tumor properties of primary macrophages.

    ID gène
    3665
    UniProt
    Q92985
    Pathways
    Signalisation TLR, Activation of Innate immune Response, Hepatitis C, Toll-Like Receptors Cascades, Autophagy
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