TLR3 anticorps (AA 801-905)

N° du produit ABIN686617

Cet anticorps Lapin Polyclonal détecte spécifiquement TLR3 dans WB, ELISA, FACS, IHC (p), IF (cc), IF (p) et IHC (fro). Il présente une réactivité envers Humain, Souris et Rat et a été mentionné dans 4+ publications.

Aperçu rapide pour TLR3 anticorps (AA 801-905) (ABIN686617)

Antigène: TLR3 (Toll-Like Receptor 3 (TLR3))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TLR3 est non-conjugé

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Détail du produit anti-TLR3 anticorps

Épitope: AA 801-905

Réactivité croisée: Humain, Souris, Rat

Homologie: Dog,Pig

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from mouse TLR3

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Références pour anticorps anti-TLR3 (ABIN686617)

Zhao, Zhang, Wang, Jin, Zhou, Chen, Su: "Activation of Toll-like receptor 3 promotes pathological corneal neovascularization by enhancement of SDF-1-mediated endothelial progenitor cell recruitment." dans: Experimental eye research, Vol. 178, pp. 177-185, (2019) (PubMed).

Zhu, Xu, Jiang, Wang, Geng, Wu, Hussain, Gao, Han, Li, Lan, Ning, Zhang, Holmdahl, Meng, Lu: "Pristane induces autophagy in macrophages, promoting a STAT1-IRF1-TLR3 pathway and arthritis." dans: Clinical immunology (Orlando, Fla.), Vol. 175, pp. 56-68, (2016) (PubMed).

Wang, Lei, Zhang, Zhao, Fang, Lai, Han, Xiao, Wang: "Xenobiotic Pregnane X Receptor (PXR) Regulates Innate Immunity via Activation of NLRP3 Inflammasome in Vascular Endothelial Cells." dans: The Journal of biological chemistry, Vol. 289, Issue 43, pp. 30075-81, (2014) (PubMed).

Zhu, Meng, Jiang, Xu, Wang, Han, Lu: "Overexpression of toll-like receptor 3 in spleen is associated with experimental arthritis in rats." dans: Scandinavian journal of immunology, Vol. 76, Issue 3, pp. 263-70, (2012) (PubMed).

Détails sur TLR3

Antigène: TLR3 (Toll-Like Receptor 3 (TLR3))

Autre désignation: TLR3

Sujet:

Synonyms: AI957183, Toll-like receptor 3, CD283, Tlr3

Background: Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR3 is a nucleotide-sensing TLR which is activated by double-stranded RNA, a sign of viral infection. Acts via the adapter TRIF/TICAM1, leading to NF-kappa-B activation, IRF3 nuclear translocation, cytokine secretion and the inflammatory response (By similarity).

ID gène: 142980

UniProt: Q99MB1

Pathways: Signalisation TLR, Activation of Innate immune Response, Hepatitis C, Toll-Like Receptors Cascades