EPAS1 anticorps (AA 1-130) (FITC)

N° du produit ABIN686669

L’anticorps Lapin Polyclonal anti-EPAS1 a été validé pour WB, FACS, IF (cc) et IF (p). Il convient pour détecter EPAS1 dans des échantillons de Humain, Rat, Souris, Singe et Mouton.

Aperçu rapide pour EPAS1 anticorps (AA 1-130) (FITC) (ABIN686669)

Antigène: EPAS1 (Endothelial PAS Domain Protein 1 (EPAS1))

Reactivité: Humain, Rat, Souris, Singe, Mouton

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp EPAS1 est conjugé à/à la FITC

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Détail du produit anti-EPAS1 anticorps (FITC)

Épitope: AA 1-130

Réactivité croisée: Humain, Singe, Souris, Rat, Mouton

Homologie: Cow,Pig,Horse

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from mouse HIF2 Alpha

Isotype: IgG

Information d'application

Indications d'application: FCM 1:20-100
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur EPAS1

Antigène: EPAS1 (Endothelial PAS Domain Protein 1 (EPAS1))

Autre désignation: Hif2 alpha

Sujet:

Synonyms: HLF, HRF, MOP2, HIF2A, bHLHe73, HIF-2alpha, Endothelial PAS domain-containing protein 1, EPAS-1, HIF-1-alpha-like factor, mHLF, HIF-related factor, Hypoxia-inducible factor 2-alpha, HIF-2-alpha, HIF2-alpha, Epas1

Background: Transcription factor involved in the induction of oxygen regulated genes. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. Regulates the vascular endothelial growth factor (VEGF) expression and seems to be implicated in the development of blood vessels and the tubular system of lung. May also play a role in the formation of the endothelium that gives rise to the blood brain barrier. Potent activator of the Tie-2 tyrosine kinase expression. Activation requires recruitment of transcriptional coactivators such as CREBPB and probably EP3. Interaction with redox regulatory protein APEX seems to activate CTAD (By similarity).

ID gène: 13819

UniProt: P97481

Pathways: Signaling Events mediated by VEGFR1 and VEGFR2, L'effet Warburg