Annexin a1 anticorps

N° du produit ABIN6936419

Cet anticorps Souris Monoclonal détecte spécifiquement Annexin a1 dans FACS et IHC (f). Il présente une réactivité envers Humain.

Aperçu rapide pour Annexin a1 anticorps (ABIN6936419)

Antigène: Annexin a1 (ANXA1) (Annexin A1 (ANXA1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Annexin a1 est non-conjugé

Application: Flow Cytometry (FACS), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))

Clone: 6E4-3

Détail du produit anti-Annexin a1 anticorps

Specificité: The ANXA1 gene belongs to the annexin family, and contains 4 annexin repeats. A pair of annexin repeats may form one binding site for calcium and a phospholipid. ANXA1 promotes membrane fusion and is involved in exocytosis. The gene for ANXA1 is upregulated in hairy cell leukemia (HCL), and its protein expression is specific for HCL. Detection of ANXA1 provides a simple, highly sensitive and specific assay for diagnosing HCL. Annexin A1 has also been found to be protective against DNA damage induced by heat in breast cancer cells, suggesting it is involved in tumor suppressive and protective activities, and also is associated with treatment resistance.

Réactivité croisée (Details): Human.

Purification: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogène: Mixture of native proteins from human bone tissues

Isotype: IgG1 kappa

Information d'application

Indications d'application:

Known_Application: Flow Cytometry (1-2 μg/million cells),Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 min at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes), Optimal dilution for a specific application should be determined.

Positive_Control: HeLa, A431, K562 cells, human esophagus, placenta and prostate tissues.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Agent conservateur: Azide free

Stock: -20 °C,-80 °C

Stockage commentaire: Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Date de péremption: 24 months

Détails sur Annexin a1

Antigène: Annexin a1 (ANXA1) (Annexin A1 (ANXA1))

Autre désignation: ANXA1

Sujet: ANXA1, ANX1, Annexin-1, Chromobindin-9, LPC1, p35,Annexin A1 / (Hairy Cell Leukemia Marker)
Cellular localisation: Nuclear and Cytoplasmic

Poids moléculaire: 35kDa

ID gène: 301, 494173

UniProt: P04083

Pathways: Hormone Transport