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C4A anticorps

C4a Reactivité: Humain ELISA, Coat, IHC (f) Hôte: Souris Monoclonal C4D204 unconjugated
N° du produit ABIN6936544
  • Antigène Voir toutes C4A (C4a) Anticorps
    C4A (C4a) (Complement Fragment C4a (C4a))
    Reactivité
    • 19
    • 6
    • 2
    • 2
    Humain
    Hôte
    • 18
    • 5
    • 1
    Souris
    Clonalité
    • 17
    • 7
    Monoclonal
    Conjugué
    • 17
    • 3
    • 2
    • 1
    • 1
    Cet anticorp C4A est non-conjugé
    Application
    • 15
    • 14
    • 10
    • 10
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    ELISA, Coating (Coat), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))
    Specificité
    This MAb is specific to Complement 4d (C4d) and reacts with the secreted as well as cell-bound C4d.C4d is a degradation product of the activated complement factor C4b. Complement 4b is typically activated by binding of Abs to specific target molecules. Following activation and degradation of the C4 Molecule, thio-ester groups are exposed, which allow transient, covalent binding of the degradation product Complement 4d to endothelial cell surfaces and extracellular matrix components of vascular basement membranes near the sites of C4 activation. The presence of C4d in peritubular capillaries is a key indicator for acute humoral (i.e. antibody-mediated) rejection of kidney, heart, pancreas and lung allografts. As an established marker of antibody-mediated acute renal allograft rejection and its proclivity for endothelium, this component can be detected in peritubular capillaries in chronic renal allograft rejection as well as hyperacute rejection, acute vascular rejection, acute cellular rejection, and borderline rejection. It has been shown to be a significant predictor of transplant kidney graft survival. Anti-C4d, combined with anti-C3d, can be utilized as a tool for diagnosis of allograft rejection that may warrant a prompt and aggressive anti-rejection treatment.
    Réactivité croisée (Details)
    Human.
    Purification
    1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
    Immunogène
    Recombinant full-length human Complement 4d protein
    Clone
    C4D204
    Isotype
    IgG1 kappa
    Top Product
    Discover our top product C4a Anticorps primaire
  • Indications d'application

    Known_Application: ELISA (For coating use Ab at 1-2 μg/mL order Ab without BSA), Immunohistochemistry (Formalin-fixed) (1:200-1:400 for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 1 mM EDTA, pH 7.5-8.5, for 45 min at 95°C followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

    Positive_Control: Rejected Renal Transplant Tissue.

    Restrictions
    For Research Use only
  • Concentration
    1.0 mg/mL
    Buffer
    Prepared in 10 mM PBS, WITHOUT BSA and Azide.
    Agent conservateur
    Azide free
    Stock
    -20 °C,-80 °C
    Stockage commentaire
    Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
    Date de péremption
    24 months
  • Antigène
    C4A (C4a) (Complement Fragment C4a (C4a))
    Autre désignation
    C4A (C4a Produits)
    Synonymes
    anticorps C4, anticorps C4A2, anticorps C4A3, anticorps C4A4, anticorps C4A6, anticorps C4AD, anticorps C4S, anticorps CO4, anticorps CPAMD2, anticorps RG, anticorps Slp, anticorps C4-1, anticorps C4b, anticorps complement C4A (Rodgers blood group), anticorps complement component 4A (Rodgers blood group), anticorps C4A, anticorps C4a
    Sujet
    Acidic Complement C4, Basic C4, C4-1, C4a Anaphylatoxin, C4A, C4A2, C4A3, C4A4, C4A6, C4b, C4B1, C4B12, C4d fragment, C4F, C4S, Complement C4 Gamma Chain, Complement Component 4A, Complement Component 4B,Complement 4d (C4d) (Acute Humoral Rejection Marker)
    Cellular localisation: Intracytoplasmic vacuoles of endothelial cells and Secreted
    Poids moléculaire
    192kDa (predicted)
    ID gène
    720, 721, 534847
    Pathways
    Système du Complément
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