CA8 anticorps

N° du produit ABIN6936553

Cet anticorps anti-CA8 est un anticorps Souris Monoclonal détectant CA8 dans WB et IHC (f). Adapté pour Humain.

Aperçu rapide pour CA8 anticorps (ABIN6936553)

Antigène: CA8 (Carbonic Anhydrase VIII (CA8))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CA8 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))

Clone: CPTC-CA8-2

Détail du produit anti-CA8 anticorps

Specificité: The protein encoded by this gene was initially named CA-related protein because of sequence similarity to other known carbonic anhydrase genes. However, the gene product lacks carbonic anhydrase activity (i.e., the reversible hydration of carbon dioxide). The gene product continues to carry a carbonic anhydrase designation based on clear sequence identity to other members of the carbonic anhydrase gene family. The absence of CA8 gene transcription in the cerebellum of the lurcher mutant in mice with a neurologic defect suggests an important role for this acatalytic form. Mutations in CA8 gene causes neuropathology, such as ataxia, mild mental retardation and the predisposition to quadrupedal gait. It is also associated with the development of colorectal and lung cancers. Additionally, it is upregulated in various cancers.

Réactivité croisée (Details): Human.

Purification: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogène: Recombinant full-length human CA8 protein

Isotype: IgG2a kappa

Information d'application

Indications d'application:

Known_Application: Western Blot (1-2 μg/mL), ,Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95 °C followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.

Positive_Control: Human cerebellum. Selective expression in purkinje cells. HEK-293 or K-562 cell lines.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Agent conservateur: Azide free

Stock: -20 °C,-80 °C

Stockage commentaire: Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Date de péremption: 24 months

Détails sur CA8

Antigène: CA8 (Carbonic Anhydrase VIII (CA8))

Autre désignation: CA8

Sujet: CA-VIII, CALS, CARP, MGC120502, MGC99509,Carbonic Anhydrase VIII
Cellular localisation: Cytoplasm. Cell surface.

Poids moléculaire: 32.97kDa

ID gène: 767, 654388

UniProt: P35219