CD40 anticorps

N° du produit ABIN6936711

L’anticorps anti-CD40 Monoclonal Rat est utilisé pour la détection de CD40 dans des échantillons de Souris. Il a été validé pour FACS, IF et Func.

Aperçu rapide pour CD40 anticorps (ABIN6936711)

Antigène: CD40

Reactivité: Souris

Hôte: Rat

Clonalité: Monoclonal

Conjugué: Cet anticorp CD40 est non-conjugé

Application: Flow Cytometry (FACS), Immunofluorescence (IF), Functional Studies (Func)

Clone: FGK45-5

Détail du produit anti-CD40 anticorps

Fonction: CD40, Mouse Antibody

Specificité: Upon binding to its ligand CD154, CD40 acts as a costimulatory molecule for the activation of B cells, dendritic cells, monocytes, and other APCs. CD40 plays roles in B cell activation, differentiation, proliferation and Ig isotype switching as well as dendritic cell maturation. FGK4.5 can be used for blocking of CD40/CD154 interaction and forin vitroandin vivoactivation of CD40 expressing APCs. This MAb is shown to indirectly activate natural killer (NK) cells, producing significant antitumor and anti-metastatic effects. Effective in boosting immune responses against infectious agents and can potentially be used to treat chronic autoimmune inflammatory processes.

Aucune reactivité croisée: Humain

Purification: 200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G.

Immunogène: Purified recombinant Mouse CD40 fusion protein

Isotype: IgG2a, kappa

Information d'application

Indications d'application:

Positive Control: MPBMC's. Spleen, Thymus or Lymph Node.

Known Application: Functional Studies (Order Antibody without BSA & Azide); Flow Cytometry (0.5-1ug/million cells in 0.1ml); Immunofluorescence (0.5-1ug/ml)Optimal dilution for a specific application should be determined.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Agent conservateur: Azide free

Stock: -20 °C,-80 °C

Stockage commentaire: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Date de péremption: 24 months

Détails sur CD40

Antigène: CD40

Autre désignation: CD40

Sujet:

B cell surface antigen CD40, CD40 type II isoform, p50, Bp50, CD40L receptor, CDW40, TRAP, IMD3, IGM, Tnfrsf5, HIGM1, GP39, T-BAM

MPBMC's. Spleen, Thymus or Lymph Node.

Poids moléculaire: 48kDa

ID gène: 21939

UniProt: P27512

Pathways: Signalisation NF-kappaB, Cellular Response to Molecule of Bacterial Origin, M Phase, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Cancer Immune Checkpoints